1ma8: Difference between revisions

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[[Image:1ma8.gif|left|200px]]
{{Seed}}
[[Image:1ma8.png|left|200px]]


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{{STRUCTURE_1ma8|  PDB=1ma8  |  SCENE=  }}  
{{STRUCTURE_1ma8|  PDB=1ma8  |  SCENE=  }}  


'''A-DNA decamer GCGTA(UMS)ACGC with incorporated 2'-methylseleno-uridine'''
===A-DNA decamer GCGTA(UMS)ACGC with incorporated 2'-methylseleno-uridine===




==Overview==
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Selenium was incorporated into an oligodeoxynucleotide in the form of 2'-methylseleno-uridine (U(Se)). The X-ray crystal structure of the duplex left open bracket d(GCGTA)U(Se)d(ACGC) right open bracket (2) was determined by the multiwavelength anomalous dispersion (MAD) technique and refined to a resolution of 1.3 A, demonstrating that selenium can selectively substitute oxygen in DNA and that the resulting compounds are chemically stable. Since derivatization at the 2'-alpha-position with selenium does not affect the preference of the sugar for the C3'-endo conformation, this strategy is suitable for incorporating selenium into RNA. The availability of selenium-containing nucleic acids for crystallographic phasing offers an attractive alternative to the commonly used halogenated pyrimidines.
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{{ABSTRACT_PUBMED_12458077}}


==About this Structure==
==About this Structure==
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[[Category: Wilds, C J.]]
[[Category: Wilds, C J.]]
[[Category: 2'-methylseleno-uridine]]
[[Category: 2'-methylseleno-uridine]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:49:12 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:32:38 2008''

Revision as of 20:32, 2 July 2008

File:1ma8.png

Template:STRUCTURE 1ma8

A-DNA decamer GCGTA(UMS)ACGC with incorporated 2'-methylseleno-uridine

Template:ABSTRACT PUBMED 12458077

About this Structure

Full crystallographic information is available from OCA.

Reference

Covalent incorporation of selenium into oligonucleotides for X-ray crystal structure determination via MAD: proof of principle. Multiwavelength anomalous dispersion., Teplova M, Wilds CJ, Wawrzak Z, Tereshko V, Du Q, Carrasco N, Huang Z, Egli M, Biochimie. 2002 Sep;84(9):849-58. PMID:12458077

Page seeded by OCA on Wed Jul 2 23:32:38 2008

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