1mf6: Difference between revisions

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[[Image:1mf6.jpg|left|200px]]
{{Seed}}
[[Image:1mf6.png|left|200px]]


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{{STRUCTURE_1mf6|  PDB=1mf6  |  SCENE=  }}  
{{STRUCTURE_1mf6|  PDB=1mf6  |  SCENE=  }}  


'''Transducin gamma subunit, C-terminal domain 60-71, rhodopsin-bound state: Ensemble of 15 models determined by TrNOE spectroscopy'''
===Transducin gamma subunit, C-terminal domain 60-71, rhodopsin-bound state: Ensemble of 15 models determined by TrNOE spectroscopy===




==Overview==
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Rhodopsin, a prototypical G protein-coupled receptor, catalyzes the activation of a heterotrimeric G protein, transducin, to initiate a visual signaling cascade in photoreceptor cells. The betagamma subunit complex, especially the C-terminal domain of the transducin gamma subunit, Gtgamma(60-71)farnesyl, plays a pivotal role in allosteric regulation of nucleotide exchange on the transducin alpha subunit by light-activated rhodopsin. We report that this domain is unstructured in the presence of an inactive receptor but forms an amphipathic helix upon rhodopsin activation. A K65E/E66K charge reversal mutant of the gamma subunit has diminished interactions with the receptor and fails to adopt the helical conformation. The identification of this conformational switch provides a mechanism for active GPCR utilization of the betagamma complex in signal transfer to G proteins.
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{{ABSTRACT_PUBMED_12679015}}


==About this Structure==
==About this Structure==
1MF6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MF6 OCA].  
1MF6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MF6 OCA].  


==Reference==
==Reference==
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[[Category: Rhodopsin]]
[[Category: Rhodopsin]]
[[Category: Transducin]]
[[Category: Transducin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:57:45 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:50:13 2008''

Revision as of 20:50, 2 July 2008

File:1mf6.png

Template:STRUCTURE 1mf6

Transducin gamma subunit, C-terminal domain 60-71, rhodopsin-bound state: Ensemble of 15 models determined by TrNOE spectroscopy

Template:ABSTRACT PUBMED 12679015

About this Structure

1MF6 is a Single protein structure of sequence from Bos taurus. Full experimental information is available from OCA.

Reference

Rhodopsin controls a conformational switch on the transducin gamma subunit., Kisselev OG, Downs MA, Structure. 2003 Apr;11(4):367-73. PMID:12679015

Page seeded by OCA on Wed Jul 2 23:50:13 2008

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