1mk1: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
Line 1: Line 1:
[[Image:1mk1.jpg|left|200px]]
{{Seed}}
[[Image:1mk1.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1mk1|  PDB=1mk1  |  SCENE=  }}  
{{STRUCTURE_1mk1|  PDB=1mk1  |  SCENE=  }}  


'''Structure of the MT-ADPRase in complex with ADPR, a Nudix enzyme'''
===Structure of the MT-ADPRase in complex with ADPR, a Nudix enzyme===




==Overview==
<!--
Nudix hydrolases are a family of proteins that contain the characteristic sequence GX(5)EX(7)REUXEEXG(I/L/V), the Nudix box. They catalyze the hydrolysis of a variety of nucleoside diphosphate derivatives such as ADP-ribose, Ap(n)A (3 &lt;/= n &lt;/= 6), NADH, and dATP. A number of Nudix hydrolases from several species, ranging from bacteria to humans, have been characterized, including, in some cases, the determination of their three-dimensional structures. The product of the Rv1700 gene of M. tuberculosis is a Nudix hydrolase specific for ADP-ribose (ADPR). We have determined the crystal structures of MT-ADPRase alone, and in complex with substrate, with substrate and the nonactivating metal ion Gd(3+), and in complex with a nonhydrolyzable ADPR analog and the activating metal ion Mn(2+). These structures, refined with data extending to resolutions between 2.0 and 2.3 A, showed that there are sequence differences in binding site residues between MT-ADPRase and a human homolog that may be exploited for antituberculosis drug development.
The line below this paragraph, {{ABSTRACT_PUBMED_12906832}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12906832 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_12906832}}


==About this Structure==
==About this Structure==
Line 35: Line 39:
[[Category: Nudix hydrolase]]
[[Category: Nudix hydrolase]]
[[Category: Rv1700]]
[[Category: Rv1700]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:15:04 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:09:09 2008''

Revision as of 21:09, 2 July 2008

File:1mk1.png

Template:STRUCTURE 1mk1

Structure of the MT-ADPRase in complex with ADPR, a Nudix enzyme

Template:ABSTRACT PUBMED 12906832

About this Structure

1MK1 is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of MT-ADPRase, a nudix hydrolase from Mycobacterium tuberculosis., Kang LW, Gabelli SB, Cunningham JE, O'Handley SF, Amzel LM, Structure. 2003 Aug;11(8):1015-23. PMID:12906832

Page seeded by OCA on Thu Jul 3 00:09:09 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1mk1&oldid=630889"