1mp8: Difference between revisions

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[[Image:1mp8.jpg|left|200px]]
{{Seed}}
[[Image:1mp8.png|left|200px]]


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{{STRUCTURE_1mp8|  PDB=1mp8  |  SCENE=  }}  
{{STRUCTURE_1mp8|  PDB=1mp8  |  SCENE=  }}  


'''Crystal structure of Focal Adhesion Kinase (FAK)'''
===Crystal structure of Focal Adhesion Kinase (FAK)===




==Overview==
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Protein kinases are important drug targets in human cancers, inflammation, and metabolic diseases. This report presents the structures of kinase domains for three cancer-associated protein kinases: ephrin receptor A2 (EphA2), focal adhesion kinase (FAK), and Aurora-A. The expression profiles of EphA2, FAK, and Aurora-A in carcinomas suggest that inhibitors of these kinases may have inherent potential as therapeutic agents. The structures were determined from crystals grown in nanovolume droplets, which produced high-resolution diffraction data at 1.7, 1.9, and 2.3 A for FAK, Aurora-A, and EphA2, respectively. The FAK and Aurora-A structures are the first determined within two unique subfamilies of human kinases, and all three structures provide new insights into kinase regulation and the design of selective inhibitors.
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{{ABSTRACT_PUBMED_12467573}}


==About this Structure==
==About this Structure==
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[[Category: Thompson, D A.]]
[[Category: Thompson, D A.]]
[[Category: Tyrosine protein kinase]]
[[Category: Tyrosine protein kinase]]
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