1mpx: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
Line 1: Line 1:
[[Image:1mpx.gif|left|200px]]
{{Seed}}
[[Image:1mpx.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1mpx|  PDB=1mpx  |  SCENE=  }}  
{{STRUCTURE_1mpx|  PDB=1mpx  |  SCENE=  }}  


'''ALPHA-AMINO ACID ESTER HYDROLASE LABELED WITH SELENOMETHIONINE'''
===ALPHA-AMINO ACID ESTER HYDROLASE LABELED WITH SELENOMETHIONINE===




==Overview==
<!--  
alpha-Amino acid ester hydrolases (AEHs) catalyze the hydrolysis and synthesis of esters and amides with an alpha-amino group. As such, they can synthesize beta-lactam antibiotics from acyl compounds and beta-lactam nuclei obtained from the hydrolysis of natural antibiotics. This article describes the gene sequence and the 1.9-A resolution crystal structure of the AEH from Xanthomonas citri. The enzyme consists of an alpha/beta-hydrolase fold domain, a helical cap domain, and a jellyroll beta-domain. Structural homology was observed to the Rhodococcus cocaine esterase, indicating that both enzymes belong to the same class of bacterial hydrolases. Docking of a beta-lactam antibiotic in the active site explains the substrate specificity, specifically the necessity of an alpha-amino group on the substrate, and explains the low specificity toward the beta-lactam nucleus.
The line below this paragraph, {{ABSTRACT_PUBMED_12684501}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12684501 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_12684501}}


==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Jellyroll]]
[[Category: Jellyroll]]
[[Category: Selenomethionine]]
[[Category: Selenomethionine]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:34:37 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:46:53 2008''

Revision as of 21:47, 2 July 2008

File:1mpx.png

Template:STRUCTURE 1mpx

ALPHA-AMINO ACID ESTER HYDROLASE LABELED WITH SELENOMETHIONINE

Template:ABSTRACT PUBMED 12684501

About this Structure

1MPX is a Single protein structure of sequence from Xanthomonas citri. Full crystallographic information is available from OCA.

Reference

The sequence and crystal structure of the alpha-amino acid ester hydrolase from Xanthomonas citri define a new family of beta-lactam antibiotic acylases., Barends TR, Polderman-Tijmes JJ, Jekel PA, Hensgens CM, de Vries EJ, Janssen DB, Dijkstra BW, J Biol Chem. 2003 Jun 20;278(25):23076-84. Epub 2003 Apr 8. PMID:12684501

Page seeded by OCA on Thu Jul 3 00:46:53 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1mpx&oldid=631739"