1mqd: Difference between revisions

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[[Image:1mqd.~~jpg~~|left|200px]]

[[Image:1mqd.png|left|200px]]

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~~'''~~X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.46 A resolution. Crystallization in the presence of lithium sulfate.~~'''~~

===X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.46 A resolution. Crystallization in the presence of lithium sulfate.===

~~==Overview==~~

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~~X-ray structures of~~ the ~~GluR2 ligand-binding core in complex with~~ (~~S)-Des-Me-AMPA and in the presence and absence of zinc ions have been determined~~. (S)~~-Des-Me-AMPA~~, ~~which~~ is ~~devoid of a substituent in~~ the 5-~~position of the isoxazolol ring, only has limited interactions with the partly hydrophobic pocket of the ligand~~-binding site, and adopts an AMPA-like binding mode. The structures, in comparison with other agonist complex structures, disclose the relative importance of the isoxazolol ring and of the substituent in the 5-position for the mode of binding. A relationship appears to exist between the extent of interaction of the ligand with the hydrophobic pocket and the affinity of the ligand.

The line below this paragraph, {{ABSTRACT_PUBMED_12417307}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12417307 is the PubMed ID number.

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==About this Structure==

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[[Category: Ionotropic glutamate receptor glur2]]

[[Category: Ligand-binding core]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May~~ 3 01:35:42 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:57:17 2008''

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-[[Image:1mqd.jpg|left|200px]]
+{{Seed}}
+[[Image:1mqd.png|left|200px]]
 <!--
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 {{STRUCTURE_1mqd|  PDB=1mqd  |  SCENE=  }}
-'''X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.46 A resolution. Crystallization in the presence of lithium sulfate.'''
+===X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.46 A resolution. Crystallization in the presence of lithium sulfate.===
-==Overview==
+<!--
-X-ray structures of the GluR2 ligand-binding core in complex with (S)-Des-Me-AMPA and in the presence and absence of zinc ions have been determined. (S)-Des-Me-AMPA, which is devoid of a substituent in the 5-position of the isoxazolol ring, only has limited interactions with the partly hydrophobic pocket of the ligand-binding site, and adopts an AMPA-like binding mode. The structures, in comparison with other agonist complex structures, disclose the relative importance of the isoxazolol ring and of the substituent in the 5-position for the mode of binding. A relationship appears to exist between the extent of interaction of the ligand with the hydrophobic pocket and the affinity of the ligand.
+The line below this paragraph, {{ABSTRACT_PUBMED_12417307}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12417307 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12417307}}
 ==About this Structure==
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 [[Category: Ionotropic glutamate receptor glur2]]
 [[Category: Ligand-binding core]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:35:42 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul  3 00:57:17 2008''