3hck: Difference between revisions

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[[Image:3hck.gif|left|200px]]
{{Seed}}
[[Image:3hck.png|left|200px]]


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{{STRUCTURE_3hck|  PDB=3hck  |  SCENE=  }}  
{{STRUCTURE_3hck|  PDB=3hck  |  SCENE=  }}  


'''NMR ENSEMBLE OF THE UNCOMPLEXED HUMAN HCK SH2 DOMAIN, 20 STRUCTURES'''
===NMR ENSEMBLE OF THE UNCOMPLEXED HUMAN HCK SH2 DOMAIN, 20 STRUCTURES===




==Overview==
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The hematopoietic cellular kinase (Hck) is a member of the Src family of non-receptor protein-tyrosine kinases and participates in signal transduction events regulating the growth, differentiation and function of phagocytes. The secondary structure of the SH2 domain for Hck was determined for a 13C/15N-enriched sample using multi-dimensional NMR spectroscopy. The secondary structure for the domain was determined from chemical shift indices [1H alpha, 13C alpha and 13C'], sequential NOEs [d(alphaN)(i, i+1) and d(NN)(i, i+1)], and 3J(alphaN) scalar coupling constants. The Hck SH2 domain consists of two alpha-helices and seven beta-strands. Complementary strands of beta-sheets were identified from long-range NOEs using a novel 3D, 13C/15N-edited HMQC-NOESY-(HCACO)NH experiment that correlated 1H alpha resonances between beta-strands. The secondary structure for Hck SH2 is similar to that predicted from the sequence alignment of the Src-family protein tyrosine kinases.
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{{ABSTRACT_PUBMED_9109402}}


==About this Structure==
==About this Structure==
3HCK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HCK OCA].  
3HCK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HCK OCA].  


==Reference==
==Reference==
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Tyrosine kinase]]
[[Category: Tyrosine kinase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:03:37 2008''
 
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