3hsc: Difference between revisions

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[[Image:3hsc.jpg|left|200px]]
{{Seed}}
[[Image:3hsc.png|left|200px]]


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{{STRUCTURE_3hsc|  PDB=3hsc  |  SCENE=  }}  
{{STRUCTURE_3hsc|  PDB=3hsc  |  SCENE=  }}  


'''THREE-DIMENSIONAL STRUCTURE OF THE ATPASE FRAGMENT OF A 70K HEAT-SHOCK COGNATE PROTEIN'''
===THREE-DIMENSIONAL STRUCTURE OF THE ATPASE FRAGMENT OF A 70K HEAT-SHOCK COGNATE PROTEIN===




==Overview==
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The three-dimensional structure of the amino-terminal 44K ATPase fragment of the 70K bovine heat-shock cognate protein has been solved to a resolution of 2.2 A. The ATPase fragment has two structural lobes with a deep cleft between them; ATP binds at the base of the cleft. Surprisingly, the nucleotide-binding 'core' of the ATPase fragment has a tertiary structure similar to that of hexokinase, although the remainder of the structures of the two proteins are completely dissimilar, suggesting that both the phosphotransferase mechanism and the substrate-induced conformational change intrinsic to the hexokinases may be used by the 70K heat shock-related proteins.
The line below this paragraph, {{ABSTRACT_PUBMED_2143562}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_2143562}}


==About this Structure==
==About this Structure==
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[[Category: Flaherty, K M.]]
[[Category: Flaherty, K M.]]
[[Category: Mckay, D B.]]
[[Category: Mckay, D B.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:04:09 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 12:49:44 2008''

Revision as of 09:49, 3 July 2008

File:3hsc.png

Template:STRUCTURE 3hsc

THREE-DIMENSIONAL STRUCTURE OF THE ATPASE FRAGMENT OF A 70K HEAT-SHOCK COGNATE PROTEIN

Template:ABSTRACT PUBMED 2143562

About this Structure

3HSC is a Single protein structure of sequence from Bos taurus. This structure supersedes the now removed PDB entries and 1hsc. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein., Flaherty KM, DeLuca-Flaherty C, McKay DB, Nature. 1990 Aug 16;346(6285):623-8. PMID:2143562

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