3php: Difference between revisions

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[[Image:3php.~~gif~~|left|200px]]

[[Image:3php.png|left|200px]]

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~~'''~~STRUCTURE OF THE 3' HAIRPIN OF THE TYMV PSEUDOKNOT: PREFORMATION IN RNA FOLDING~~'''~~

===STRUCTURE OF THE 3' HAIRPIN OF THE TYMV PSEUDOKNOT: PREFORMATION IN RNA FOLDING===

~~==Overview==~~

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The ~~solution structure of an RNA-hairpin present in the pseudoknot~~, ~~which is found at the 3'-terminus of turnip yellow mosaic virus genomic RNA~~, ~~has been solved by nuclear magnetic resonance spectroscopy. The loop, which contains~~ the ~~sequence 5'-GGGUCA-3', was found to be highly structured and, contrary~~ to ~~expectations, does not attain its stability through GA or GC base pair formation but by triple interactions between~~ the ~~tilted adenosine and the minor groove sides of the first two guanosines~~. ~~Interestingly~~, ~~a very similar conformation was found for~~ the ~~cognate pseudoknot, implying that the 3'~~-~~hairpin is preformed for folding into a pseudoknotted structure. These findings suggest a mechanism of 'predetermined~~-~~fit' as a principle in RNA folding.~~

The line below this paragraph, {{ABSTRACT_PUBMED_9857204}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9857204 is the PubMed ID number.

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==About this Structure==

Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHP OCA].

Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHP OCA].

==Reference==

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[[Category: Rna]]

[[Category: Tymv]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May~~ ~~4 22~~:10~~:30~~ 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:02:10 2008''

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-[[Image:3php.gif|left|200px]]
+{{Seed}}
+[[Image:3php.png|left|200px]]
 <!--
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 {{STRUCTURE_3php|  PDB=3php  |  SCENE=  }}
-'''STRUCTURE OF THE 3' HAIRPIN OF THE TYMV PSEUDOKNOT: PREFORMATION IN RNA FOLDING'''
+===STRUCTURE OF THE 3' HAIRPIN OF THE TYMV PSEUDOKNOT: PREFORMATION IN RNA FOLDING===
-==Overview==
+<!--
-The solution structure of an RNA-hairpin present in the pseudoknot, which is found at the 3'-terminus of turnip yellow mosaic virus genomic RNA, has been solved by nuclear magnetic resonance spectroscopy. The loop, which contains the sequence 5'-GGGUCA-3', was found to be highly structured and, contrary to expectations, does not attain its stability through GA or GC base pair formation but by triple interactions between the tilted adenosine and the minor groove sides of the first two guanosines. Interestingly, a very similar conformation was found for the cognate pseudoknot, implying that the 3'-hairpin is preformed for folding into a pseudoknotted structure. These findings suggest a mechanism of 'predetermined-fit' as a principle in RNA folding.
+The line below this paragraph, {{ABSTRACT_PUBMED_9857204}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9857204 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9857204}}
 ==About this Structure==
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHP OCA].
+Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHP OCA].
 ==Reference==
@@ Line 30: / Line 34: @@
 [[Category: Rna]]
 [[Category: Tymv]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 22:10:30 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul  3 13:02:10 2008''