3psr: Difference between revisions

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[[Image:3psr.gif|left|200px]]
{{Seed}}
[[Image:3psr.png|left|200px]]


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{{STRUCTURE_3psr|  PDB=3psr  |  SCENE=  }}  
{{STRUCTURE_3psr|  PDB=3psr  |  SCENE=  }}  


'''HUMAN PSORIASIN (S100A7) CA2+ BOUND FORM (CRYSTAL FORM I)'''
===HUMAN PSORIASIN (S100A7) CA2+ BOUND FORM (CRYSTAL FORM I)===




==Overview==
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The crystal structure of human psoriasin (S100A7) in the native, calcium-bound form has been determined from two crystal forms of the protein crystallized with and without divalent zinc. The overall structures of the dimeric protein closely resemble the previously determined holmium-substituted structure. The structures also reveal a zinc-binding site of the protein, which is formed by three histidines and an aspartate residue. Together, these residues coordinate the zinc ion in a way similar to the pattern seen in certain metalloproteases and in particular the collagenase family of proteins. Sequence comparison suggests that this zinc site is present in a number of the remaining members of the S100 family. The structure of S100A7 crystallized in the absence of zinc further shows that loss of zinc results in a reorganization of the adjacent empty and distorted EF-hand loop, causing it to resemble a calcium-loaded EF-hand.
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==About this Structure==
==About this Structure==
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[[Category: S100 protein family]]
[[Category: S100 protein family]]
[[Category: X-ray crystallography]]
[[Category: X-ray crystallography]]
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Revision as of 10:03, 3 July 2008

File:3psr.png

Template:STRUCTURE 3psr

HUMAN PSORIASIN (S100A7) CA2+ BOUND FORM (CRYSTAL FORM I)

Template:ABSTRACT PUBMED 10026247

About this Structure

3PSR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Zinc-binding site of an S100 protein revealed. Two crystal structures of Ca2+-bound human psoriasin (S100A7) in the Zn2+-loaded and Zn2+-free states., Brodersen DE, Nyborg J, Kjeldgaard M, Biochemistry. 1999 Feb 9;38(6):1695-704. PMID:10026247

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