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| [[Image:422d.gif|left|200px]] | | {{Seed}} |
| | [[Image:422d.png|left|200px]] |
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| {{STRUCTURE_422d| PDB=422d | SCENE= }} | | {{STRUCTURE_422d| PDB=422d | SCENE= }} |
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| '''5'-R(*GP*AP*UP*CP*AP*CP*UP*UP*CP*GP*GP*U)-3''''
| | ===5'-R(*GP*AP*UP*CP*AP*CP*UP*UP*CP*GP*GP*U)-3'=== |
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| ==Overview==
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| The crystal structure of an RNA dodecamer, r(GAUCACUUCGGU), was solved at 2.6 A resolution by the molecular-replacement method and refined to an R(work) of 18.8% (R(free) = 22.8%) using 2494 reflections. The dodecamer crystallized in the monoclinic space group C2, with unit-cell parameters a = 71.34, b = 39.98, c = 32.47 A, beta = 104.7 degrees and two independent strands in the asymmetric unit. The dodecamer adopts an octamer duplex structure with four 5'-overhang residues (G1A2U3C4), which form Watson-Crick base pairs with another four 5'-overhang residues of a symmetry-related duplex. The octamer duplex (ACUUCGGU) contains at its center four mismatched base pairs flanked by two Watson-Crick base pairs. The mismatched bases form two G.U wobble base pairs at the ends and two U.C base pairs at the center, with one base-base hydrogen bond N4(C).O4(U) and a water bridge connecting the N(3) of the cytosine and uridine. The present study reinforces the concept of the stability of the conformation of UUCG in RNA double-helical structures. | | The line below this paragraph, {{ABSTRACT_PUBMED_14684886}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 14684886 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_14684886}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Sundaralingam, M.]] | | [[Category: Sundaralingam, M.]] |
| [[Category: Double helix]] | | [[Category: Double helix]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:17:04 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:17:26 2008'' |
