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| [[Image:425d.gif|left|200px]] | | {{Seed}} |
| | [[Image:425d.png|left|200px]] |
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| {{STRUCTURE_425d| PDB=425d | SCENE= }} | | {{STRUCTURE_425d| PDB=425d | SCENE= }} |
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| '''5'-D(*AP*CP*CP*GP*GP*TP*AP*CP*CP*GP*GP*T)-3''''
| | ===5'-D(*AP*CP*CP*GP*GP*TP*AP*CP*CP*GP*GP*T)-3'=== |
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| ==Overview==
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| Transcriptional regulation in papillomaviruses depends on sequence-specific binding of the regulatory protein E2 to several sites in the viral genome. Crystal structures of bovine papillomavirus E2 DNA targets reveal a conformational variant of B-DNA characterized by a roll-induced writhe and helical repeat of 10.5 bp per turn. A comparison between the free and the protein-bound DNA demonstrates that the intrinsic structure of the DNA regions contacted directly by the protein and the deformability of the DNA region that is not contacted by the protein are critical for sequence-specific protein/DNA recognition and hence for gene-regulatory signals in the viral system. We show that the selection of dinucleotide or longer segments with appropriate conformational characteristics, when positioned at correct intervals along the DNA helix, can constitute a structural code for DNA recognition by regulatory proteins. This structural code facilitates the formation of a complementary protein-DNA interface that can be further specified by hydrogen bonds and nonpolar interactions between the protein amino acids and the DNA bases.
| | The line below this paragraph, {{ABSTRACT_PUBMED_9860945}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 9860945 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_9860945}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Shakked, Z.]] | | [[Category: Shakked, Z.]] |
| [[Category: Double helix]] | | [[Category: Double helix]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:17:09 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:17:48 2008'' |
