437d: Difference between revisions

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[[Image:437d.~~gif~~|left|200px]]

[[Image:437d.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF AN RNA PSEUDOKNOT FROM BEET WESTERN YELLOW VIRUS INVOLVED IN RIBOSOMAL FRAMESHIFTING~~'''~~

===CRYSTAL STRUCTURE OF AN RNA PSEUDOKNOT FROM BEET WESTERN YELLOW VIRUS INVOLVED IN RIBOSOMAL FRAMESHIFTING===

~~==Overview==~~

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~~Many viruses regulate translation of polycistronic mRNA using a~~ -~~1 ribosomal frameshift induced by an RNA pseudoknot. A pseudoknot has two stems that form a quasi~~-~~continuous helix and two connecting loops. A 1.6 A crystal structure of~~ the ~~beet western yellow virus~~ (~~BWYV) pseudoknot reveals rotation and a bend~~ at ~~the junction of the two stems~~. ~~A loop base~~ is ~~inserted in~~ the ~~major groove of one stem with quadruple-base interactions~~. ~~The second loop forms a new minor~~-~~groove triplex motif with the other stem, involving 2'~~-OH and triple-base interactions, as well as sodium ion coordination. Overall, the number of hydrogen bonds stabilizing the tertiary interactions exceeds the number involved in Watson-Crick base pairs. This structure will aid mechanistic analyses of ribosomal frameshifting.

The line below this paragraph, {{ABSTRACT_PUBMED_10074948}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10074948 is the PubMed ID number.

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==About this Structure==

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[[Category: Triplex]]

[[Category: Viral frameshifting]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May~~ ~~4 22~~:17:47 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:19:31 2008''

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-[[Image:437d.gif|left|200px]]
+{{Seed}}
+[[Image:437d.png|left|200px]]
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 {{STRUCTURE_437d|  PDB=437d  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF AN RNA PSEUDOKNOT FROM BEET WESTERN YELLOW VIRUS INVOLVED IN RIBOSOMAL FRAMESHIFTING'''
+===CRYSTAL STRUCTURE OF AN RNA PSEUDOKNOT FROM BEET WESTERN YELLOW VIRUS INVOLVED IN RIBOSOMAL FRAMESHIFTING===
-==Overview==
+<!--
-Many viruses regulate translation of polycistronic mRNA using a -1 ribosomal frameshift induced by an RNA pseudoknot. A pseudoknot has two stems that form a quasi-continuous helix and two connecting loops. A 1.6 A crystal structure of the beet western yellow virus (BWYV) pseudoknot reveals rotation and a bend at the junction of the two stems. A loop base is inserted in the major groove of one stem with quadruple-base interactions. The second loop forms a new minor-groove triplex motif with the other stem, involving 2'-OH and triple-base interactions, as well as sodium ion coordination. Overall, the number of hydrogen bonds stabilizing the tertiary interactions exceeds the number involved in Watson-Crick base pairs. This structure will aid mechanistic analyses of ribosomal frameshifting.
+The line below this paragraph, {{ABSTRACT_PUBMED_10074948}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10074948 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10074948}}
 ==About this Structure==
@@ Line 29: / Line 33: @@
 [[Category: Triplex]]
 [[Category: Viral frameshifting]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 22:17:47 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul  3 13:19:31 2008''