454d: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
[[Image:454d.gif|left|200px]]
{{Seed}}
[[Image:454d.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_454d|  PDB=454d  |  SCENE=  }}  
{{STRUCTURE_454d|  PDB=454d  |  SCENE=  }}  


'''INTERCALATION AND MAJOR GROOVE RECOGNITION IN THE 1.2 A RESOLUTION CRYSTAL STRUCTURE OF RH[ME2TRIEN]PHI BOUND TO 5'-G(5IU)TGCAAC-3''''
===INTERCALATION AND MAJOR GROOVE RECOGNITION IN THE 1.2 A RESOLUTION CRYSTAL STRUCTURE OF RH[ME2TRIEN]PHI BOUND TO 5'-G(5IU)TGCAAC-3'===




==Overview==
<!--
Intercalating complexes of rhodium(III) are strong photo-oxidants that promote DNA strand cleavage or electron transfer through the double helix. The 1.2 A resolution crystal structure of a sequence-specific rhodium intercalator bound to a DNA helix provides a rationale for the sequence specificity of rhodium intercalators. It also explains how intercalation in the center of an oligonucleotide modifies DNA conformation. The rhodium complex intercalates via the major groove where specific contacts are formed with the edges of the bases at the target site. The phi ligand is deeply inserted into the DNA base pair stack. The primary conformational change of the DNA is a doubling of the rise per residue, with no change in sugar pucker from B-form DNA. Based upon the five crystallographically independent views of an intercalated DNA helix observed in this structure, the intercalator may be considered as an additional base pair with specific functional groups positioned in the major groove.
The line below this paragraph, {{ABSTRACT_PUBMED_10655613}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10655613 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_10655613}}


==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Metallointercalator]]
[[Category: Metallointercalator]]
[[Category: Photoexcitable]]
[[Category: Photoexcitable]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:18:35 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:21:47 2008''

Revision as of 10:21, 3 July 2008

File:454d.png

Template:STRUCTURE 454d

INTERCALATION AND MAJOR GROOVE RECOGNITION IN THE 1.2 A RESOLUTION CRYSTAL STRUCTURE OF RH[ME2TRIEN]PHI BOUND TO 5'-G(5IU)TGCAAC-3'

Template:ABSTRACT PUBMED 10655613

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of a photoactive rhodium complex intercalated into DNA., Kielkopf CL, Erkkila KE, Hudson BP, Barton JK, Rees DC, Nat Struct Biol. 2000 Feb;7(2):117-21. PMID:10655613

Page seeded by OCA on Thu Jul 3 13:21:47 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=454d&oldid=634162"