459d: Difference between revisions

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[[Image:459d.gif|left|200px]]
{{Seed}}
[[Image:459d.png|left|200px]]


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{{STRUCTURE_459d|  PDB=459d  |  SCENE=  }}  
{{STRUCTURE_459d|  PDB=459d  |  SCENE=  }}  


'''DNA MINOR-GROOVE RECOGNITION OF A TRIS-BENZIMIDAZOLE DRUG'''
===DNA MINOR-GROOVE RECOGNITION OF A TRIS-BENZIMIDAZOLE DRUG===




==Overview==
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The crystal structure of the non-self-complementary dodecamer DNA duplex formed by d(CG[5BrC]ATAT-TTGCG) and d(CGCAAATATGCG) has been solved to 2.3 A resolution, together with that of its complex with the tris-benzimidazole minor groove binding ligand TRIBIZ. The inclusion of a bromine atom on one strand in each structure enabled the possibility of disorder to be discounted. The native structure has an exceptional narrow minor groove, of 2.5-2.6 A in the central part of the A/T region, which is increased in width by approximately 0.8 A on drug binding. The ligand molecule binds in the central part of the sequence. The benzimidazole subunits of the ligand participate in six bifurcated hydrogen bonds with A:T base pair edges, three to each DNA strand. The presence of a pair of C-H...O hydrogen bonds has been deduced from the close proximity of the pyrrolidine group of the ligand to the TpA step in the sequence.
The line below this paragraph, {{ABSTRACT_PUBMED_10373586}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10373586 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10373586}}


==About this Structure==
==About this Structure==
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[[Category: Deoxyribonucleic acid]]
[[Category: Deoxyribonucleic acid]]
[[Category: Minor groove binding]]
[[Category: Minor groove binding]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:18:53 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:22:45 2008''

Revision as of 10:22, 3 July 2008

File:459d.png

Template:STRUCTURE 459d

DNA MINOR-GROOVE RECOGNITION OF A TRIS-BENZIMIDAZOLE DRUG

Template:ABSTRACT PUBMED 10373586

About this Structure

Full crystallographic information is available from OCA.

Reference

DNA minor groove recognition of a non-self-complementary AT-rich sequence by a tris-benzimidazole ligand., Aymami J, Nunn CM, Neidle S, Nucleic Acids Res. 1999 Jul 1;27(13):2691-8. PMID:10373586

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