4wbc: Difference between revisions

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[[Image:4wbc.jpg|left|200px]]
{{Seed}}
[[Image:4wbc.png|left|200px]]


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{{STRUCTURE_4wbc|  PDB=4wbc  |  SCENE=  }}  
{{STRUCTURE_4wbc|  PDB=4wbc  |  SCENE=  }}  


'''2.13 A STRUCTURE OF A KUNITZ-TYPE WINGED BEAN CHYMOTRYPSIN INHIBITOR PROTEIN'''
===2.13 A STRUCTURE OF A KUNITZ-TYPE WINGED BEAN CHYMOTRYPSIN INHIBITOR PROTEIN===




==Overview==
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The crystal structure of a Kunitz-type double-headed alpha--chymotrypsin inhibitor from winged bean seeds has been refined at 2.13 A resolution using data collected from cryo-cooled (90 K) crystals which belong to the hexagonal space group P6(1)22 with unit-cell parameters a = b = 60.84, c = 207.91 A. The volume of the unit cell is reduced by 5.3% on cooling. The refinement converged to an R value of 20.0% (R(free) = 25.8%) for 11100 unique reflections and the model shows good stereochemistry, with r.m.s. deviations from ideal values for bond lengths and bond angles of 0.011 A and 1.4 degrees, respectively. The structural architecture of the protein consists of 12 antiparallel beta-strands joined in the form of a characteristic beta-trefoil fold, with the two reactive-site regions, Asn38-Leu43 and Gln63-Phe68, situated on two external loops. Although the overall protein fold is the same as that of the room-temperature model, some conformational changes are observed in the loop regions and in the side chains of a few surface residues. A total of 176 ordered water molecules and five sulfate ions are included in the model.
The line below this paragraph, {{ABSTRACT_PUBMED_10531477}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_10531477}}


==About this Structure==
==About this Structure==
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[[Category: Sen, U.]]
[[Category: Sen, U.]]
[[Category: Serine protease inhibitor]]
[[Category: Serine protease inhibitor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:31:12 2008''
 
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Revision as of 10:54, 3 July 2008

File:4wbc.png

Template:STRUCTURE 4wbc

2.13 A STRUCTURE OF A KUNITZ-TYPE WINGED BEAN CHYMOTRYPSIN INHIBITOR PROTEIN

Template:ABSTRACT PUBMED 10531477

About this Structure

4WBC is a Single protein structure of sequence from Psophocarpus tetragonolobus. This structure supersedes the now removed PDB entry 3wbc. Full crystallographic information is available from OCA.

Reference

Cryocrystallography of a Kunitz-type serine protease inhibitor: the 90 K structure of winged bean chymotrypsin inhibitor (WCI) at 2.13 A resolution., Ravichandran S, Sen U, Chakrabarti C, Dattagupta JK, Acta Crystallogr D Biol Crystallogr. 1999 Nov;55(Pt 11):1814-21. PMID:10531477

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