5bna: Difference between revisions

Line 1:

[[Image:5bna.~~jpg~~|left|200px]]

[[Image:5bna.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~THE PRIMARY MODE OF BINDING OF CISPLATIN TO A B-DNA DODECAMER: C-G-C-G-A-A-T-T-C-G-C-G~~'''~~

===THE PRIMARY MODE OF BINDING OF CISPLATIN TO A B-DNA DODECAMER: C-G-C-G-A-A-T-T-C-G-C-G===

~~==Overview==~~

<!--

~~When cisplatin [cis~~- ~~diamminodichloroplatinum (II)] is diffused into pre~~-~~grown crystals of the B-DNA double-helical dodecamer C-G-C-G-A-A-T-T-C-G-C-G~~, ~~it binds preferentially to the N7 positions of guanines~~, ~~with what probably is an aquo bridge between Pt and~~ the ~~adjacent O6 atom of~~ the ~~same guanine~~. ~~The entire guanine ring moves slightly toward the platinum site, into the major groove~~. ~~Only three of the eight potential cisplatin binding sites on guanines actually are occupied~~, ~~and this differential reactivity can be explained in terms of the relative freedom of motion of guanines toward~~ the ~~major groove. This shift of guanines upon ligation may weaken the glycosyl bond and assist in the depurination that leads to mismatch SOS repair and G.C. to T.A. transversion~~.

The line below this paragraph, {{ABSTRACT_PUBMED_6539674}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 6539674 is the PubMed ID number.

-->

==About this Structure==

Line 28:

Line 32:

[[Category: Double helix]]

[[Category: Modified]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May~~ ~~4 22~~:32:14 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:57:17 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:5bna.jpg|left|200px]]
+{{Seed}}
+[[Image:5bna.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_5bna|  PDB=5bna  |  SCENE=  }}
-'''THE PRIMARY MODE OF BINDING OF CISPLATIN TO A B-DNA DODECAMER: C-G-C-G-A-A-T-T-C-G-C-G'''
+===THE PRIMARY MODE OF BINDING OF CISPLATIN TO A B-DNA DODECAMER: C-G-C-G-A-A-T-T-C-G-C-G===
-==Overview==
+<!--
-When cisplatin [cis- diamminodichloroplatinum (II)] is diffused into pre-grown crystals of the B-DNA double-helical dodecamer C-G-C-G-A-A-T-T-C-G-C-G, it binds preferentially to the N7 positions of guanines, with what probably is an aquo bridge between Pt and the adjacent O6 atom of the same guanine. The entire guanine ring moves slightly toward the platinum site, into the major groove. Only three of the eight potential cisplatin binding sites on guanines actually are occupied, and this differential reactivity can be explained in terms of the relative freedom of motion of guanines toward the major groove. This shift of guanines upon ligation may weaken the glycosyl bond and assist in the depurination that leads to mismatch SOS repair and G.C. to T.A. transversion.
+The line below this paragraph, {{ABSTRACT_PUBMED_6539674}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 6539674 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_6539674}}
 ==About this Structure==
@@ Line 28: / Line 32: @@
 [[Category: Double helix]]
 [[Category: Modified]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 22:32:14 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul  3 13:57:17 2008''