5rhn: Difference between revisions

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[[Image:5rhn.png|left|200px]]

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~~'''~~HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH 8-BR-AMP~~'''~~

===HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH 8-BR-AMP===

~~==Overview==~~

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~~Histidine triad nucleotide-binding protein (HINT)~~, ~~a dimeric purine nucleotide-binding protein from rabbit heart~~, ~~is a member of~~ the ~~HIT~~ (~~histidine triad) superfamily which includes HINT homologues and FHIT (HIT protein encoded~~ at ~~the chromosome 3 fragile site) homologues~~. Crystal structures of HINT-nucleotide complexes demonstrate that the most conserved residues in the superfamily mediate nucleotide binding and that the HIT motif forms part of the phosphate binding loop. ~~Galactose-1-phosphate uridylyltransferase~~, ~~whose deficiency causes galactosemia, contains tandem HINT domains with~~ the ~~same fold and mode of nucleotide binding as HINT despite having no overall sequence similarity~~. ~~Features of FHIT, a diadenosine polyphosphate hydrolase and candidate tumour suppressor, are predicted from HINT~~-~~nucleotide structures.~~

The line below this paragraph, {{ABSTRACT_PUBMED_9164465}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9164465 is the PubMed ID number.

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==About this Structure==

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[[Category: Ringe, D.]]

[[Category: Nucleotide-binding protein]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May~~ ~~4 22~~:37:28 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 14:10:20 2008''

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-[[Image:5rhn.gif|left|200px]]
+{{Seed}}
+[[Image:5rhn.png|left|200px]]
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 {{STRUCTURE_5rhn|  PDB=5rhn  |  SCENE=  }}
-'''HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH 8-BR-AMP'''
+===HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH 8-BR-AMP===
-==Overview==
+<!--
-Histidine triad nucleotide-binding protein (HINT), a dimeric purine nucleotide-binding protein from rabbit heart, is a member of the HIT (histidine triad) superfamily which includes HINT homologues and FHIT (HIT protein encoded at the chromosome 3 fragile site) homologues. Crystal structures of HINT-nucleotide complexes demonstrate that the most conserved residues in the superfamily mediate nucleotide binding and that the HIT motif forms part of the phosphate binding loop. Galactose-1-phosphate uridylyltransferase, whose deficiency causes galactosemia, contains tandem HINT domains with the same fold and mode of nucleotide binding as HINT despite having no overall sequence similarity. Features of FHIT, a diadenosine polyphosphate hydrolase and candidate tumour suppressor, are predicted from HINT-nucleotide structures.
+The line below this paragraph, {{ABSTRACT_PUBMED_9164465}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9164465 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9164465}}
 ==About this Structure==
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 [[Category: Ringe, D.]]
 [[Category: Nucleotide-binding protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 22:37:28 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul  3 14:10:20 2008''