7ins: Difference between revisions

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[[Image:7ins.~~gif~~|left|200px]]

[[Image:7ins.png|left|200px]]

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~~'''~~STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z~~'''~~

===STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z===

~~==Overview==~~

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The ~~crystal structure of NPH-insulin, pig insulin cocrystallized with zinc~~, ~~m-cresol and protamine~~, has been solved by molecular replacement and refined using restrained least-squares refinement methods. The final crystallographic R factor for all reflections between 2 and 10 A is 19.4%. The insulin molecules are arranged as hexamers with two tetrahedrally coordinated Zn atoms in the ~~central channel and one m-cresol bound~~ to ~~each monomer near His B5~~. ~~One protamine binding site has been unequivocally identified near a dimer-dimer interface~~, ~~although most of the polypeptide~~ is ~~crystallographically disordered. The conformation of the insulin moiety and the structural differences between~~ the ~~three unique monomers have been analysed~~. ~~The zinc and m~~-~~cresol environments are described and the nature of the protamine binding site is outlined.~~

The line below this paragraph, {{ABSTRACT_PUBMED_1772633}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 1772633 is the PubMed ID number.

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==About this Structure==

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[[Category: Korber, F.]]

[[Category: Hormone]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May~~ ~~4 22~~:46:20 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 14:40:18 2008''

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-[[Image:7ins.gif|left|200px]]
+{{Seed}}
+[[Image:7ins.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_7ins|  PDB=7ins  |  SCENE=  }}
-'''STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z'''
+===STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z===
-==Overview==
+<!--
-The crystal structure of NPH-insulin, pig insulin cocrystallized with zinc, m-cresol and protamine, has been solved by molecular replacement and refined using restrained least-squares refinement methods. The final crystallographic R factor for all reflections between 2 and 10 A is 19.4%. The insulin molecules are arranged as hexamers with two tetrahedrally coordinated Zn atoms in the central channel and one m-cresol bound to each monomer near His B5. One protamine binding site has been unequivocally identified near a dimer-dimer interface, although most of the polypeptide is crystallographically disordered. The conformation of the insulin moiety and the structural differences between the three unique monomers have been analysed. The zinc and m-cresol environments are described and the nature of the protamine binding site is outlined.
+The line below this paragraph, {{ABSTRACT_PUBMED_1772633}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 1772633 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_1772633}}
 ==About this Structure==
@@ Line 28: / Line 32: @@
 [[Category: Korber, F.]]
 [[Category: Hormone]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 22:46:20 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul  3 14:40:18 2008''