2rli: Difference between revisions

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[[Image:2rli.jpg|left|200px]]
{{Seed}}
[[Image:2rli.png|left|200px]]


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{{STRUCTURE_2rli|  PDB=2rli  |  SCENE=  }}  
{{STRUCTURE_2rli|  PDB=2rli  |  SCENE=  }}  


'''Solution structure of Cu(I) human Sco2'''
===Solution structure of Cu(I) human Sco2===




==Overview==
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Human Sco2 is a mitochondrial membrane-bound protein involved in copper supply for the assembly of cytochrome c oxidase in eukaryotes. Its precise action is not yet understood. We report here a structural and dynamic characterization by NMR of the apo and copper(I) forms of the soluble fragment. The structural and metal binding features of human Cu(I)Sco2 are similar to the more often studied Sco1 homolog, although the dynamic properties and the conformational disorder are quite different when the apo forms and the copper(I)-loaded forms of the two proteins are compared separately. Such differences are accounted for in terms of the different physicochemical properties in strategic protein locations. The misfunction of the known pathogenic mutations is discussed on the basis of the obtained structure.
The line below this paragraph, {{ABSTRACT_PUBMED_17850752}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17850752 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17850752}}


==Disease==
==Disease==
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==About this Structure==
==About this Structure==
2RLI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLI OCA].  
2RLI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLI OCA].  


==Reference==
==Reference==
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[[Category: Structural proteomics in europe]]
[[Category: Structural proteomics in europe]]
[[Category: Thioredoxin fold]]
[[Category: Thioredoxin fold]]
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