398d: Difference between revisions

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[[Image:398d.gif|left|200px]]
{{Seed}}
[[Image:398d.png|left|200px]]


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{{STRUCTURE_398d|  PDB=398d  |  SCENE=  }}  
{{STRUCTURE_398d|  PDB=398d  |  SCENE=  }}  


'''3'-DNA-RNA-5' JUNCTION FORMED DURING INITIATION OF MINUS-STRAND SYNTHESIS OF HIV REPLICATION'''
===3'-DNA-RNA-5' JUNCTION FORMED DURING INITIATION OF MINUS-STRAND SYNTHESIS OF HIV REPLICATION===




==Overview==
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During initiation of minus-strand synthesis by HIV-1 reverse transcriptase, a 3'-DNA-RNA-5' junction is formed involving the 3'-end of tRNAlys,3. The HIV-RT-associated RNase H cleaves the RNA template strand specifically, opposite the newly synthesized DNA strand. We have determined the crystal structure at 1.9 A resolution of an eight-base pair hybrid duplex representing the junction to identify global or local structural perturbations which may be recognized by HIV-RT RNase H. The junction octamer is in a global A-type conformation throughout. A base pair step with distinct stacking geometry and variable backbone conformation is located next to the main endonucleolytic cleavage site. This base pair step may serve as a recognition site for HIV-RT RNase H.
The line below this paragraph, {{ABSTRACT_PUBMED_9724510}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9724510 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9724510}}


==About this Structure==
==About this Structure==
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[[Category: A-dna/rna]]
[[Category: A-dna/rna]]
[[Category: Double helix]]
[[Category: Double helix]]
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