2eyy: Difference between revisions

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[[Image:2eyy.jpg|left|200px]]
{{Seed}}
[[Image:2eyy.png|left|200px]]


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{{STRUCTURE_2eyy|  PDB=2eyy  |  SCENE=  }}  
{{STRUCTURE_2eyy|  PDB=2eyy  |  SCENE=  }}  


'''CT10-Regulated Kinase isoform I'''
===CT10-Regulated Kinase isoform I===




==Overview==
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CRKI (SH2-SH3) and CRKII (SH2-SH3-SH3) are splicing isoforms of the oncoprotein CRK that regulate transcription and cytoskeletal reorganization for cell growth and motility by linking tyrosine kinases to small G proteins. CRKI shows substantial transforming activity, whereas the activity of CRKII is low, and phosphorylated CRKII has no biological activity whatsoever. The molecular mechanisms underlying the distinct biological activities of the CRK proteins remain elusive. We determined the solution structures of CRKI, CRKII and phosphorylated CRKII by NMR and identified the molecular mechanism that gives rise to their activities. Results from mutational analysis using rodent 3Y1 fibroblasts were consistent with those from the structural studies. Together, these data suggest that the linker region modulates the binding of CRKII to its targets, thus regulating cell growth and motility.
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{{ABSTRACT_PUBMED_17515907}}


==About this Structure==
==About this Structure==
2EYY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYY OCA].  
2EYY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYY OCA].  


==Reference==
==Reference==
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[[Category: Sh2]]
[[Category: Sh2]]
[[Category: Sh3]]
[[Category: Sh3]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:16:06 2008''
[[Category: Signaling protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 9 10:04:12 2008''
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