1pc3: Difference between revisions

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[[Image:1pc3.gif|left|200px]]
{{Seed}}
[[Image:1pc3.png|left|200px]]


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{{STRUCTURE_1pc3|  PDB=1pc3  |  SCENE=  }}  
{{STRUCTURE_1pc3|  PDB=1pc3  |  SCENE=  }}  


'''Crystal structure of the extracellular phosphate ABC transport receptor (PstS-1) and immunodominant antigen of M. tuberculosis.'''
===Crystal structure of the extracellular phosphate ABC transport receptor (PstS-1) and immunodominant antigen of M. tuberculosis.===




==Overview==
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The 2.16 A structure of the phosphate-bound PstS-1, the primary extracellular receptor for the ABC phosphate transporter and immunodominant species-specific antigen of Mycobacterium tuberculosis, has been determined. The phosphate, completely engulfed in the cleft between two domains, is bound by 13 hydrogen bonds, 11 of which are formed with NH and OH dipolar donor groups. The further presence of two acidic residues, which serve as acceptors of the protonated phosphate, is key to conferring stringent specificity. The ion-dipole interactions between the phosphate and dipolar groups compensate the ligand's isolated negative charges. Moreover, the surprise finding that the electrostatic surface in and around the cleft is intensely negative demonstrates the power of ion-dipole interactions in anion binding and electrostatic balance. Additional functional features include both the flexible N-terminal segment that tethers PstS-1 on the cell surface and the hinge between the two domains, which should facilitate snaring the phosphate in the medium.
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{{ABSTRACT_PUBMED_12842040}}


==About this Structure==
==About this Structure==
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[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Phosphate transport receptor]]
[[Category: Phosphate transport receptor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:55:32 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 10 12:40:20 2008''

Revision as of 09:40, 10 July 2008

File:1pc3.png

Template:STRUCTURE 1pc3

Crystal structure of the extracellular phosphate ABC transport receptor (PstS-1) and immunodominant antigen of M. tuberculosis.

Template:ABSTRACT PUBMED 12842040

About this Structure

1PC3 is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Crystal structure of M tuberculosis ABC phosphate transport receptor: specificity and charge compensation dominated by ion-dipole interactions., Vyas NK, Vyas MN, Quiocho FA, Structure. 2003 Jul;11(7):765-74. PMID:12842040

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