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| {{STRUCTURE_1vyb| PDB=1vyb | SCENE= }} | | {{STRUCTURE_1vyb| PDB=1vyb | SCENE= }} |
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| '''ENDONUCLEASE DOMAIN OF HUMAN LINE1 ORF2P'''
| | ===ENDONUCLEASE DOMAIN OF HUMAN LINE1 ORF2P=== |
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| ==Overview==
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| The human L1 endonuclease (L1-EN) is encoded by the non-LTR retrotransposon LINE-1 (L1). L1 is responsible for more than 1.5 million retrotransposition events in the history of the human genome, contributing more than a quarter to human genomic DNA (L1 and Alu elements). L1-EN is related to the well-understood human DNA repair endonuclease APE1, and its nicking specificity is a major determinant for retrotransposon integration site selection. The crystal structure of human L1 endonuclease is the first of a retrotransposon-encoded protein and a prototype for retrotransposon-encoded endonucleases involved in target-primed reverse transcription. Structure-based endonuclease alignments reveal a conserved threonine in addition to previously identified invariant residues and suggest that DNA recognition proceeds via the accommodation of an extrahelical nucleotide within a pocket of the enzyme. The present analysis will help to refine phylogenetic and functional relationships among metal-dependent phosphohydrolases and provides a basis for manipulating non-LTR retrotransposon integration site selection. | | The line below this paragraph, {{ABSTRACT_PUBMED_15274918}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 15274918 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_15274918}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Rna-directed dna polymerase]] | | [[Category: Rna-directed dna polymerase]] |
| [[Category: Transferase]] | | [[Category: Transferase]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:54:34 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 10 12:53:11 2008'' |
