Sandbox 14: Difference between revisions
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== | {{STRUCTURE_1wsu | PDB=1wsu | SCENE=Goodsell_Sandbox/1wsu-recognition1/3 }} | ||
Molecular Recognition in SelB | |||
<scene name=' | Elongation factor SelB uses several methods to recognize the selenocysteine insertion sequence found in messenger RNA. The insertion sequence forms a hairpin loop with an unstacked guanine base in the loop. This guanine forms | ||
<scene name='Goodsell_Sandbox/1wsu-recognition1/3'>specific hydrogen bonds with the protein and with two bridging water molecules (shown in cyan in the jmol).</scene> | |||
The planar base is also sandwiched between | |||
<scene name='Goodsell_Sandbox/1wsu-recognition2/1'>three amino acids</scene>in the protein, which form a tight hydrophobic pocket. This is best seen using a | |||
<scene name='Goodsell_Sandbox/1wsu-recognition3/1'>spacefilling diagram.</scene> | |||
The overall shape of the hairpin is recognized by contacts with several | |||
<scene name='Goodsell_Sandbox/1wsu-recognition4/1'>arginine and lysine amino acids.</scene> | |||
In particular, notice the intimate contact formed by both the charged nitrogen and hydrophobic carbon chain of | |||
<scene name='Goodsell_Sandbox/1wsu-recognition5/1'>arginine 606.</scene> | |||
