|
|
| Line 1: |
Line 1: |
| [[Image:1p58.gif|left|200px]] | | {{Seed}} |
| | [[Image:1p58.png|left|200px]] |
|
| |
|
| <!-- | | <!-- |
| Line 9: |
Line 10: |
| {{STRUCTURE_1p58| PDB=1p58 | SCENE= }} | | {{STRUCTURE_1p58| PDB=1p58 | SCENE= }} |
|
| |
|
| '''Complex Organization of Dengue Virus Membrane Proteins as Revealed by 9.5 Angstrom Cryo-EM reconstruction'''
| | ===Complex Organization of Dengue Virus Membrane Proteins as Revealed by 9.5 Angstrom Cryo-EM reconstruction=== |
|
| |
|
|
| |
|
| ==Overview==
| | <!-- |
| Improved technology for reconstructing cryo-electron microscopy (cryo-EM) images has now made it possible to determine secondary structural features of membrane proteins in enveloped viruses. The structure of mature dengue virus particles was determined to a resolution of 9.5 A by cryo-EM and image reconstruction techniques, establishing the secondary structural disposition of the 180 envelope (E) and 180 membrane (M) proteins in the lipid envelope. The alpha-helical 'stem' regions of the E molecules, as well as part of the N-terminal section of the M proteins, are buried in the outer leaflet of the viral membrane. The 'anchor' regions of E and the M proteins each form antiparallel E-E and M-M transmembrane alpha-helices, leaving their C termini on the exterior of the viral membrane, consistent with the predicted topology of the unprocessed polyprotein. This is one of only a few determinations of the disposition of transmembrane proteins in situ and shows that the nucleocapsid core and envelope proteins do not have a direct interaction in the mature virus.
| | The line below this paragraph, {{ABSTRACT_PUBMED_14528291}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 14528291 is the PubMed ID number. |
| | --> |
| | {{ABSTRACT_PUBMED_14528291}} |
|
| |
|
| ==About this Structure== | | ==About this Structure== |
| Line 39: |
Line 43: |
| [[Category: Icosahedral virus]] | | [[Category: Icosahedral virus]] |
| [[Category: Membrane protein m]] | | [[Category: Membrane protein m]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:42:08 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 07:58:56 2008'' |
