3b8z: Difference between revisions

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[[Image:3b8z.jpg|left|200px]]
{{Seed}}
[[Image:3b8z.png|left|200px]]


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{{STRUCTURE_3b8z|  PDB=3b8z  |  SCENE=  }}  
{{STRUCTURE_3b8z|  PDB=3b8z  |  SCENE=  }}  


'''High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2)'''
===High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2)===




==Overview==
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Aggrecanase-2 (a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5)), a member of the ADAMTS protein family, is critically involved in arthritic diseases because of its direct role in cleaving the cartilage component aggrecan. The catalytic domain of aggrecanase-2 has been refolded, purified, and crystallized, and its three-dimensional structure determined to 1.4A resolution in the presence of an inhibitor. A high resolution structure of an ADAMTS/aggrecanase protein provides an opportunity for the development of therapeutics to treat osteoarthritis.
The line below this paragraph, {{ABSTRACT_PUBMED_17991750}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_17991750}}


==About this Structure==
==About this Structure==
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[[Category: Alpha/beta]]
[[Category: Alpha/beta]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:32:03 2008''
 
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