2ca7: Difference between revisions

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[[Image:2ca7.gif|left|200px]]
{{Seed}}
[[Image:2ca7.png|left|200px]]


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{{STRUCTURE_2ca7|  PDB=2ca7  |  SCENE=  }}  
{{STRUCTURE_2ca7|  PDB=2ca7  |  SCENE=  }}  


'''CONKUNITZIN-S1 IS THE FIRST MEMBER OF A NEW KUNITZ-TYPE NEUROTOXIN FAMILY- STRUCTURAL AND FUNCTIONAL CHARACTERIZATION'''
===CONKUNITZIN-S1 IS THE FIRST MEMBER OF A NEW KUNITZ-TYPE NEUROTOXIN FAMILY- STRUCTURAL AND FUNCTIONAL CHARACTERIZATION===




==Overview==
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Conkunitzin-S1 (Conk-S1) is a 60-residue neurotoxin from the venom of the cone snail Conus striatus that interacts with voltage-gated potassium channels. Conk-S1 shares sequence homology with Kunitz-type proteins but contains only two out of the three highly conserved cysteine bridges, which are typically found in these small, basic protein modules. In this study the three-dimensional structure of Conk-S1 has been solved by multidimensional NMR spectroscopy. The solution structure of recombinant Conk-S1 shows that a Kunitz fold is present, even though one of the highly conserved disulfide cross-links is missing. Introduction of a third, homologous disulfide bond into Conk-S1 results in a functional toxin with similar affinity for Shaker potassium channels. The affinity of Conk-S1 can be enhanced by a pore mutation within the Shaker channel pore indicating an interaction of Conk-S1 with the vestibule of potassium channels.
The line below this paragraph, {{ABSTRACT_PUBMED_15833744}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15833744 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15833744}}


==About this Structure==
==About this Structure==
2CA7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_striatus Conus striatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA7 OCA].  
2CA7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_striatus Conus striatus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1yl2 1yl2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA7 OCA].  


==Reference==
==Reference==
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[[Category: Potassium channel inhibitor]]
[[Category: Potassium channel inhibitor]]
[[Category: Toxin]]
[[Category: Toxin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 21:33:41 2008''
 
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