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| [[Image:2qf4.jpg|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_2qf4| PDB=2qf4 | SCENE= }} | | {{STRUCTURE_2qf4| PDB=2qf4 | SCENE= }} |
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| '''High resolution structure of the major periplasmic domain from the cell shape-determining filament MreC (orthorhombic form)'''
| | ===High resolution structure of the major periplasmic domain from the cell shape-determining filament MreC (orthorhombic form)=== |
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| ==Overview==
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| Bacterial cell shape is dictated by the cell wall, a plastic structure that must adapt to growth and division whilst retaining its function as a selectively permeable barrier. The modulation of cell wall structure is achieved by a variety of enzymatic functions, all of which must be spatially regulated in a precise manner. The membrane-spanning essential protein MreC has been identified as the central hub in this process, linking the bacterial cytoskeleton to a variety of cell wall-modifying enzymes. Additionally, MreC can form filaments, believed to run perpendicularly to the membrane. We present here the 1.2 A resolution crystal structure of the major periplasmic domain of Streptococcus pneumoniae MreC. The protein shows a novel arrangement of two barrel-shaped domains, one of which shows homology to a known protein oligomerization motif, with the other resembling a catalytic domain from a bacterial protease. We discuss the implications of these results for MreC function, and detail the structural features of the molecule that may be responsible for the binding of partner proteins.
| | The line below this paragraph, {{ABSTRACT_PUBMED_17707860}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 17707860 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_17707860}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Filament a-lytic protease fold]] | | [[Category: Filament a-lytic protease fold]] |
| [[Category: Structural protein]] | | [[Category: Structural protein]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:51:04 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:39:10 2008'' |
