2joo: Difference between revisions

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[[Image:2joo.jpg|left|200px]]
{{Seed}}
[[Image:2joo.png|left|200px]]


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{{STRUCTURE_2joo|  PDB=2joo  |  SCENE=  }}  
{{STRUCTURE_2joo|  PDB=2joo  |  SCENE=  }}  


'''The NMR Solution Structure of Recombinant RGD-hirudin'''
===The NMR Solution Structure of Recombinant RGD-hirudin===




==Overview==
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The solution structure of a new recombinant RGD-hirudin, which has the activities of anti-thrombin and anti-platelet aggregation, was determined by (1)H nuclear magnetic resonance spectroscopy and compared with the conformations of recombinant wild-type hirudin and hirudin (variant 2, Lys47) of the hirudin thrombin complex. On the basis of total 1284 distance and dihedral angle constraints derived from a series of NMR spectra, 20 conformers were computed with ARIA/CNS programs. The structure of residues 3-30 and 37-48 form a molecular core with two antiparallel beta-sheets as the other two hirudins. However, significant differences were found in the surface electrostatic charge distributions among the three hirudins, especially in the RGD segment of recombinant RGD-hirudin. This difference may be greatly beneficial to its additional function of anti-platelet aggregation. The difference in extended C-terminal makes its both ionic and hydrophobic interactions with the fibrinogen recognition exosite of thrombin more effective.
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{{ABSTRACT_PUBMED_17585879}}


==About this Structure==
==About this Structure==
2JOO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JOO OCA].  
2JOO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JOO OCA].  


==Reference==
==Reference==
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[[Category: Blood clotting]]
[[Category: Blood clotting]]
[[Category: Mainly beta]]
[[Category: Mainly beta]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:07:23 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:41:10 2008''

Revision as of 09:41, 27 July 2008

File:2joo.png

Template:STRUCTURE 2joo

The NMR Solution Structure of Recombinant RGD-hirudin

Template:ABSTRACT PUBMED 17585879

About this Structure

2JOO is a Single protein structure of sequence from Hirudo medicinalis. Full experimental information is available from OCA.

Reference

The NMR solution structure of recombinant RGD-hirudin., Song X, Mo W, Liu X, Zhu L, Yan X, Song H, Dai L, Biochem Biophys Res Commun. 2007 Aug 17;360(1):103-8. Epub 2007 Jun 13. PMID:17585879

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