2pd8: Difference between revisions

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[[Image:2pd8.~~jpg~~|left|200px]]

[[Image:2pd8.png|left|200px]]

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~~'''~~1.8 Angstrom Crystal Structure of the Cys71Ser mutant of Vivid~~'''~~

===1.8 Angstrom Crystal Structure of the Cys71Ser mutant of Vivid===

~~==Overview==~~

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The ~~Neurospora crassa photoreceptor Vivid tunes blue-light responses and modulates gating of the circadian clock. Crystal structures of dark-state and light-state Vivid reveal a light~~, ~~oxygen~~, ~~or voltage Per-Arnt-Sim domain with an unusual N-terminal cap region and a loop insertion that accommodates~~ the ~~flavin cofactor~~. ~~Photoinduced formation of a cystein-flavin adduct drives flavin protonation to induce an N-terminal conformational change~~. ~~A cysteine-to-serine substitution remote from the flavin adenine dinucleotide binding site decouples conformational switching from~~ the ~~flavin photocycle and prevents Vivid from sending signals in Neurospora~~. ~~Key elements of this activation mechanism are conserved by other photosensors such as White Collar~~-~~1, ZEITLUPE, ENVOY, and flavin~~-~~binding, kelch repeat, F-BOX 1 (FKF1).~~

The line below this paragraph, {{ABSTRACT_PUBMED_17510367}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17510367 is the PubMed ID number.

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==About this Structure==

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[[Category: Lov domain]]

[[Category: Photoreceptor]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~May 4~~ 12:53:50 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:41:54 2008''

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-[[Image:2pd8.jpg|left|200px]]
+{{Seed}}
+[[Image:2pd8.png|left|200px]]
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 {{STRUCTURE_2pd8|  PDB=2pd8  |  SCENE=  }}
-'''1.8 Angstrom Crystal Structure of the Cys71Ser mutant of Vivid'''
+===1.8 Angstrom Crystal Structure of the Cys71Ser mutant of Vivid===
-==Overview==
+<!--
-The Neurospora crassa photoreceptor Vivid tunes blue-light responses and modulates gating of the circadian clock. Crystal structures of dark-state and light-state Vivid reveal a light, oxygen, or voltage Per-Arnt-Sim domain with an unusual N-terminal cap region and a loop insertion that accommodates the flavin cofactor. Photoinduced formation of a cystein-flavin adduct drives flavin protonation to induce an N-terminal conformational change. A cysteine-to-serine substitution remote from the flavin adenine dinucleotide binding site decouples conformational switching from the flavin photocycle and prevents Vivid from sending signals in Neurospora. Key elements of this activation mechanism are conserved by other photosensors such as White Collar-1, ZEITLUPE, ENVOY, and flavin-binding, kelch repeat, F-BOX 1 (FKF1).
+The line below this paragraph, {{ABSTRACT_PUBMED_17510367}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17510367 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17510367}}
 ==About this Structure==
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 [[Category: Lov domain]]
 [[Category: Photoreceptor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 12:53:50 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:41:54 2008''