1wit: Difference between revisions

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[[Image:1wit.jpg|left|200px]]
{{Seed}}
[[Image:1wit.png|left|200px]]


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{{STRUCTURE_1wit|  PDB=1wit  |  SCENE=  }}  
{{STRUCTURE_1wit|  PDB=1wit  |  SCENE=  }}  


'''TWITCHIN IMMUNOGLOBULIN SUPERFAMILY DOMAIN (IGSF MODULE) (IG 18'), NMR, MINIMIZED AVERAGE STRUCTURE'''
===TWITCHIN IMMUNOGLOBULIN SUPERFAMILY DOMAIN (IGSF MODULE) (IG 18'), NMR, MINIMIZED AVERAGE STRUCTURE===




==Overview==
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The NMR solution structure of an immunoglobulin superfamily module of twitchin (Ig 18') has been determined and the kinetic and equilibrium folding behaviour characterised. Thirty molecular coordinates were calculated using a hybrid distance geometry-simulated annealing protocol based on 1207 distance and 48 dihedral restraints. The atomic rms distributions about the mean coordinate for the ensemble of structures is 0.55( +/- 0.09) A for backbone atoms and 1.10( +/- 0.08) A for all heavy atoms. The protein has a topology very similar to that of telokin and the titin Ig domains and thus it falls into the I set of the immunoglobulin superfamily. The close agreement between the predicted and observed structures of Ig 18' demonstrates clearly that the I set profile can be applied in the structure prediction of immunoglobulin-like domains of diverse modular proteins. Folding studies reveal that the protein has relatively low thermodynamic stability, deltaG(H2O)U-F = 4.0 kcal mol(-1) at physiological pH. Unfolding studies suggest that the protein has considerable kinetic stability, the half life of the unfolding is greater than 40 minutes in the absence of denaturant.
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{{ABSTRACT_PUBMED_8969309}}


==About this Structure==
==About this Structure==
1WIT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WIT OCA].  
1WIT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WIT OCA].  


==Reference==
==Reference==
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[[Category: Immunoglobulin superfamily]]
[[Category: Immunoglobulin superfamily]]
[[Category: Muscle protein]]
[[Category: Muscle protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 13:44:11 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:46:41 2008''

Revision as of 09:46, 27 July 2008

File:1wit.png

Template:STRUCTURE 1wit

TWITCHIN IMMUNOGLOBULIN SUPERFAMILY DOMAIN (IGSF MODULE) (IG 18'), NMR, MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 8969309

About this Structure

1WIT is a Single protein structure of sequence from Caenorhabditis elegans. Full experimental information is available from OCA.

Reference

Structure and stability of an immunoglobulin superfamily domain from twitchin, a muscle protein of the nematode Caenorhabditis elegans., Fong S, Hamill SJ, Proctor M, Freund SM, Benian GM, Chothia C, Bycroft M, Clarke J, J Mol Biol. 1996 Dec 6;264(3):624-39. PMID:8969309

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