2gsq: Difference between revisions

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[[Image:2gsq.~~jpg~~|left|200px]]

[[Image:2gsq.png|left|200px]]

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~~'''~~GLUTATHIONE S-TRANSFERASE FROM SQUID DIGESTIVE GLAND COMPLEXED WITH S-(3-IODOBENZYL)GLUTATHIONE~~'''~~

===GLUTATHIONE S-TRANSFERASE FROM SQUID DIGESTIVE GLAND COMPLEXED WITH S-(3-IODOBENZYL)GLUTATHIONE===

~~==Overview==~~

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~~The crystal structure of the sigma class glutathione transferase from squid digestive gland in complex with S~~-(3-~~iodobenzyl)glutathione reveals a third binding site for the glutathione conjugate besides the two in the active sites of the dimer.~~ The ~~additional binding site is near~~ the ~~crystallographic two-fold axis between~~ the ~~two alpha 4-turn-alpha 5 motifs~~. The principal binding interactions with the conjugate include specific electrostatic interactions between the peptide and the two subunits and a hydrophobic cavity found across the two-fold axis that accommodates the 3-iodobenzyl group. ~~Thus~~, ~~two identical, symmetry-related but mutually exclusive binding modes for~~ the ~~third conjugate are observed~~. ~~The hydrophobic pocket is about 14 A from the hydroxyl group of Tyr~~-~~7 in the active site. This site is a potential transport binding site for hydrophobic molecules or their glutathione conjugates.~~

The line below this paragraph, {{ABSTRACT_PUBMED_8710848}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 8710848 is the PubMed ID number.

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==About this Structure==

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[[Category: Sigma class]]

[[Category: Squid digestive gland]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~May 4 05~~:29:08 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:57:24 2008''

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-[[Image:2gsq.jpg|left|200px]]
+{{Seed}}
+[[Image:2gsq.png|left|200px]]
 <!--
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 {{STRUCTURE_2gsq|  PDB=2gsq  |  SCENE=  }}
-'''GLUTATHIONE S-TRANSFERASE FROM SQUID DIGESTIVE GLAND COMPLEXED WITH S-(3-IODOBENZYL)GLUTATHIONE'''
+===GLUTATHIONE S-TRANSFERASE FROM SQUID DIGESTIVE GLAND COMPLEXED WITH S-(3-IODOBENZYL)GLUTATHIONE===
-==Overview==
+<!--
-The crystal structure of the sigma class glutathione transferase from squid digestive gland in complex with S-(3-iodobenzyl)glutathione reveals a third binding site for the glutathione conjugate besides the two in the active sites of the dimer. The additional binding site is near the crystallographic two-fold axis between the two alpha 4-turn-alpha 5 motifs. The principal binding interactions with the conjugate include specific electrostatic interactions between the peptide and the two subunits and a hydrophobic cavity found across the two-fold axis that accommodates the 3-iodobenzyl group. Thus, two identical, symmetry-related but mutually exclusive binding modes for the third conjugate are observed. The hydrophobic pocket is about 14 A from the hydroxyl group of Tyr-7 in the active site. This site is a potential transport binding site for hydrophobic molecules or their glutathione conjugates.
+The line below this paragraph, {{ABSTRACT_PUBMED_8710848}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8710848 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8710848}}
 ==About this Structure==
@@ Line 28: / Line 32: @@
 [[Category: Sigma class]]
 [[Category: Squid digestive gland]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:29:08 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:57:24 2008''