2bpv: Difference between revisions

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[[Image:2bpv.jpg|left|200px]]
{{Seed}}
[[Image:2bpv.png|left|200px]]


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{{STRUCTURE_2bpv|  PDB=2bpv  |  SCENE=  }}  
{{STRUCTURE_2bpv|  PDB=2bpv  |  SCENE=  }}  


'''HIV-1 PROTEASE-INHIBITOR COMPLEX'''
===HIV-1 PROTEASE-INHIBITOR COMPLEX===




==Overview==
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The ability to replace an inhibitor bound to the HIV-1 protease in single crystals with other potent inhibitors offers the possibility of investigating a series of protease inhibitors rapidly and conveniently with the use of X-ray crystallography. This approach affords a fast turnaround of structural information for iterative rational drug designs and obviates the need for studying the complex structures by co-crystallization. The replacement approach has been successfully used with single crystals of the HIV-1 protease complexed with a weak inhibitor. The structures of the complexes obtained by the replacement method are similar to those determined by co-crystallization.
The line below this paragraph, {{ABSTRACT_PUBMED_9757136}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9757136 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9757136}}


==About this Structure==
==About this Structure==
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[[Category: Acid protease]]
[[Category: Acid protease]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:37:43 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:09:57 2008''
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