2psr: Difference between revisions

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[[Image:2psr.~~gif~~|left|200px]]

[[Image:2psr.png|left|200px]]

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~~'''~~HUMAN PSORIASIN (S100A7) CA2+ AND ZN2+ BOUND FORM (CRYSTAL FORM II)~~'''~~

===HUMAN PSORIASIN (S100A7) CA2+ AND ZN2+ BOUND FORM (CRYSTAL FORM II)===

~~==Overview==~~

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~~The crystal structure of human psoriasin (S100A7) in the native, calcium~~-bound form has been determined from two crystal forms of the protein crystallized with and without divalent zinc. The overall structures of the dimeric protein closely resemble the previously determined holmium-~~substituted structure.~~ The ~~structures also reveal a zinc-binding site of the protein~~, ~~which is formed by three histidines and an aspartate residue. Together~~, ~~these residues coordinate~~ the ~~zinc ion in a way similar~~ to the ~~pattern seen in certain metalloproteases and in particular the collagenase family of proteins~~. ~~Sequence comparison suggests that this zinc site~~ is ~~present in a~~ number ~~of the remaining members of the S100 family~~. ~~The structure of S100A7 crystallized in the absence of zinc further shows that loss of zinc results in a reorganization of the adjacent empty and distorted EF~~-~~hand loop, causing it to resemble a calcium~~-~~loaded EF-hand.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10026247}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10026247 is the PubMed ID number.

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==About this Structure==

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[[Category: S100 protein family]]

[[Category: Zn-binding]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~May 4~~ 13:44:38 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:17:47 2008''

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-[[Image:2psr.gif|left|200px]]
+{{Seed}}
+[[Image:2psr.png|left|200px]]
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 {{STRUCTURE_2psr|  PDB=2psr  |  SCENE=  }}
-'''HUMAN PSORIASIN (S100A7) CA2+ AND ZN2+ BOUND FORM (CRYSTAL FORM II)'''
+===HUMAN PSORIASIN (S100A7) CA2+ AND ZN2+ BOUND FORM (CRYSTAL FORM II)===
-==Overview==
+<!--
-The crystal structure of human psoriasin (S100A7) in the native, calcium-bound form has been determined from two crystal forms of the protein crystallized with and without divalent zinc. The overall structures of the dimeric protein closely resemble the previously determined holmium-substituted structure. The structures also reveal a zinc-binding site of the protein, which is formed by three histidines and an aspartate residue. Together, these residues coordinate the zinc ion in a way similar to the pattern seen in certain metalloproteases and in particular the collagenase family of proteins. Sequence comparison suggests that this zinc site is present in a number of the remaining members of the S100 family. The structure of S100A7 crystallized in the absence of zinc further shows that loss of zinc results in a reorganization of the adjacent empty and distorted EF-hand loop, causing it to resemble a calcium-loaded EF-hand.
+The line below this paragraph, {{ABSTRACT_PUBMED_10026247}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10026247 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10026247}}
 ==About this Structure==
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 [[Category: S100 protein family]]
 [[Category: Zn-binding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 13:44:38 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:17:47 2008''