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[[Image:1oas.gif|left|200px]]
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[[Image:1oas.png|left|200px]]


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{{STRUCTURE_1oas|  PDB=1oas  |  SCENE=  }}  
{{STRUCTURE_1oas|  PDB=1oas  |  SCENE=  }}  


'''O-ACETYLSERINE SULFHYDRYLASE FROM SALMONELLA TYPHIMURIUM'''
===O-ACETYLSERINE SULFHYDRYLASE FROM SALMONELLA TYPHIMURIUM===




==Overview==
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The last step in cysteine biosynthesis in enteric bacteria is catalyzed by the pyridoxal 5'-phosphate-dependent enzyme O-acetylserine sulfhydrylase. Here we report the crystal structure at 2.2 A resolution of the A-isozyme of O-acetylserine sulfhydrylase isolated from Salmonella typhimurium. O-acetylserine sulfhydrylase shares the same fold with tryptophan synthase-beta from Salmonella typhimurium but the sequence identity level is below 20%. There are some major structural differences: the loops providing the interface to the alpha-subunit in tryptophan synthase-beta and two surface helices of tryptophan synthase-beta are missing in O-acetylserine sulfhydrylase. The hydrophobic channel for indole transport from the alpha to the beta active site of tryptophan synthase-beta is, not unexpectedly, also absent in O-acetylserine sulfhydrylase. The dimer interface, on the other hand, is more or less conserved in the two enzymes. The active site cleft of O-acetylserine sulfhydrylase is wider and therefore more exposed to the solvent. A possible binding site for the substrate O-acetylserine is discussed.
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{{ABSTRACT_PUBMED_9761678}}


==About this Structure==
==About this Structure==
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[[Category: Homodimer]]
[[Category: Homodimer]]
[[Category: Plp dependent enzyme]]
[[Category: Plp dependent enzyme]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:36:23 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:48:06 2008''

Revision as of 10:48, 27 July 2008

File:1oas.png

Template:STRUCTURE 1oas

O-ACETYLSERINE SULFHYDRYLASE FROM SALMONELLA TYPHIMURIUM

Template:ABSTRACT PUBMED 9761678

About this Structure

1OAS is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of O-acetylserine sulfhydrylase from Salmonella typhimurium., Burkhard P, Rao GS, Hohenester E, Schnackerz KD, Cook PF, Jansonius JN, J Mol Biol. 1998;283(1):121-33. PMID:9761678

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