2ckb: Difference between revisions

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[[Image:2ckb.gif|left|200px]]
{{Seed}}
[[Image:2ckb.png|left|200px]]


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{{STRUCTURE_2ckb|  PDB=2ckb  |  SCENE=  }}  
{{STRUCTURE_2ckb|  PDB=2ckb  |  SCENE=  }}  


'''STRUCTURE OF THE 2C/KB/DEV8 COMPLEX'''
===STRUCTURE OF THE 2C/KB/DEV8 COMPLEX===




==Overview==
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The T cell receptor (TCR) inherently has dual specificity. T cells must recognize self-antigens in the thymus during maturation and then discriminate between foreign pathogens in the periphery. A molecular basis for this cross-reactivity is elucidated by the crystal structure of the alloreactive 2C TCR bound to self peptide-major histocompatibility complex (pMHC) antigen H-2Kb-dEV8 refined against anisotropic 3.0 angstrom resolution x-ray data. The interface between peptide and TCR exhibits extremely poor shape complementarity, and the TCR beta chain complementarity-determining region 3 (CDR3) has minimal interaction with the dEV8 peptide. Large conformational changes in three of the TCR CDR loops are induced upon binding, providing a mechanism of structural plasticity to accommodate a variety of different peptide antigens. Extensive TCR interaction with the pMHC alpha helices suggests a generalized orientation that is mediated by the Valpha domain of the TCR and rationalizes how TCRs can effectively "scan" different peptides bound within a large, low-affinity MHC structural framework for those that provide the slight additional kinetic stabilization required for signaling.
The line below this paragraph, {{ABSTRACT_PUBMED_9469799}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9469799 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9469799}}


==About this Structure==
==About this Structure==
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[[Category: Major histocompatibility complex]]
[[Category: Major histocompatibility complex]]
[[Category: T cell antigen receptor]]
[[Category: T cell antigen receptor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 22:20:57 2008''
 
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Revision as of 10:56, 27 July 2008

File:2ckb.png

Template:STRUCTURE 2ckb

STRUCTURE OF THE 2C/KB/DEV8 COMPLEX

Template:ABSTRACT PUBMED 9469799

About this Structure

2CKB is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen., Garcia KC, Degano M, Pease LR, Huang M, Peterson PA, Teyton L, Wilson IA, Science. 1998 Feb 20;279(5354):1166-72. PMID:9469799

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