1nn7: Difference between revisions

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[[Image:1nn7.gif|left|200px]]
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[[Image:1nn7.png|left|200px]]


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{{STRUCTURE_1nn7|  PDB=1nn7  |  SCENE=  }}  
{{STRUCTURE_1nn7|  PDB=1nn7  |  SCENE=  }}  


'''Crystal Structure Of The Tetramerization Domain Of The Shal Voltage-Gated Potassium Channel'''
===Crystal Structure Of The Tetramerization Domain Of The Shal Voltage-Gated Potassium Channel===




==Overview==
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We have developed a semiempirical algorithm called Family Values (FamVal), which identifies residues that encode functional specificity in a protein sequence. Given a multiple sequence alignment (MSA) grouped into functionally distinct subfamilies, FamVal calculates a specificity score for each subfamily at every amino acid position of an MSA. This algorithm was used to predict specificity-encoding positions within the tetramerization assembly (T1) domain of voltage-gated potassium (Kv) channel subfamilies Kv3 and Kv4. The importance of one such position (Arg to Ala at MSA position 93) was confirmed by in vitro pull-down assays. The structural basis of this assembly discrimination was elucidated by determining the crystal structure of the Kv4 T1 domain and comparing it to the Kv3 T1 domain.
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{{ABSTRACT_PUBMED_12835418}}


==About this Structure==
==About this Structure==
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[[Category: Teteramerization domain]]
[[Category: Teteramerization domain]]
[[Category: Voltage gated potassium channel]]
[[Category: Voltage gated potassium channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:56:44 2008''

Revision as of 10:56, 27 July 2008

File:1nn7.png

Template:STRUCTURE 1nn7

Crystal Structure Of The Tetramerization Domain Of The Shal Voltage-Gated Potassium Channel

Template:ABSTRACT PUBMED 12835418

About this Structure

1NN7 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Determining the basis of channel-tetramerization specificity by x-ray crystallography and a sequence-comparison algorithm: Family Values (FamVal)., Nanao MH, Zhou W, Pfaffinger PJ, Choe S, Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8670-5. Epub 2003 Jun 30. PMID:12835418

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