2jdh: Difference between revisions

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[[Image:2jdh.gif|left|200px]]
{{Seed}}
[[Image:2jdh.png|left|200px]]


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{{STRUCTURE_2jdh|  PDB=2jdh  |  SCENE=  }}  
{{STRUCTURE_2jdh|  PDB=2jdh  |  SCENE=  }}  


'''LECTIN PA-IIL OF P.AERUGINOSA COMPLEXED WITH DISACCHARIDE DERIVATIVE'''
===LECTIN PA-IIL OF P.AERUGINOSA COMPLEXED WITH DISACCHARIDE DERIVATIVE===




==Overview==
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Pseudomonas aeruginosa is an opportunistic bacterium showing increasing resistance to antibiotics and consequently represents elevated threatening problems in hospital environments, particularly for cystic fibrosis patients. The use of glycomimetics as an anti-adhesive strategy against microorganisms may complement the use of antibiotics. PA-IIL lectin (LecB) from P. aeruginosa constitutes an appealing target for antibacterial agents, as it has been proposed to play a key role in binding to airway epithelia and/or to be involved in biofilm formation. The lectin has an unusually high affinity for L-fucose and related oligosaccharides. In the work presented herein, the disaccharide alphaFuc1-4GlcNAc is used as a scaffold toward the synthesis of a series of glycomimetic derivatives. Microcalorimetry and structural studies indicate that several of the derivatives are potent inhibitors of the lectin, with affinity in the same range as the best known natural ligand, Lewis a, and could represent interesting leads for the development of future antibacterial compounds.
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{{ABSTRACT_PUBMED_17623286}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
X-ray Structures and Thermodynamics of the Interaction of PA-IIL from Pseudomonas aeruginosa with Disaccharide Derivatives., Marotte K, Sabin C, Preville C, Moume-Pymbock M, Wimmerova M, Mitchell EP, Imberty A, Roy R, ChemMedChem. 2007 Sep 10;2(9):1328-1338. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17623286 17623286]
X-ray Structures and Thermodynamics of the Interaction of PA-IIL from Pseudomonas aeruginosa with Disaccharide Derivatives., Marotte K, Sabin C, Preville C, Moume-Pymbock M, Wimmerova M, Mitchell EP, Imberty A, Roy R, ChemMedChem. 2007 Sep 10;2(9):1328-1338. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17623286 17623286]
Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients., Mitchell E, Houles C, Sudakevitz D, Wimmerova M, Gautier C, Perez S, Wu AM, Gilboa-Garber N, Imberty A, Nat Struct Biol. 2002 Dec;9(12):918-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12415289 12415289]
Structural basis for the interaction between human milk oligosaccharides and the bacterial lectin PA-IIL of Pseudomonas aeruginosa., Perret S, Sabin C, Dumon C, Pokorna M, Gautier C, Galanina O, Ilia S, Bovin N, Nicaise M, Desmadril M, Gilboa-Garber N, Wimmerova M, Mitchell EP, Imberty A, Biochem J. 2005 Jul 15;389(Pt 2):325-32. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15790314 15790314]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Lectin]]
[[Category: Lectin]]
[[Category: Pseuomonas aeruginosa]]
[[Category: Pseuomonas aeruginosa]]
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