1zz8: Difference between revisions

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[[Image:1zz8.gif|left|200px]]
{{Seed}}
[[Image:1zz8.png|left|200px]]


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{{STRUCTURE_1zz8|  PDB=1zz8  |  SCENE=  }}  
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'''Crystal Structure of FeII HppE in Complex with Substrate Form 2'''
===Crystal Structure of FeII HppE in Complex with Substrate Form 2===




==Overview==
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The biosynthetic pathway of the clinically important antibiotic fosfomycin uses enzymes that catalyse reactions without precedent in biology. Among these is hydroxypropylphosphonic acid epoxidase, which represents a new subfamily of non-haem mononuclear iron enzymes. Here we present six X-ray structures of this enzyme: the apoenzyme at 2.0 A resolution; a native Fe(II)-bound form at 2.4 A resolution; a tris(hydroxymethyl)aminomethane-Co(II)-enzyme complex structure at 1.8 A resolution; a substrate-Co(II)-enzyme complex structure at 2.5 A resolution; and two substrate-Fe(II)-enzyme complexes at 2.1 and 2.3 A resolution. These structural data lead us to suggest how this enzyme is able to recognize and respond to its substrate with a conformational change that protects the radical-based intermediates formed during catalysis. Comparisons with other family members suggest why substrate binding is able to prime iron for dioxygen binding in the absence of alpha-ketoglutarate (a co-substrate required by many mononuclear iron enzymes), and how the unique epoxidation reaction of hydroxypropylphosphonic acid epoxidase may occur.
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==About this Structure==
==About this Structure==
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[[Category: Mononuclear iron enzyme]]
[[Category: Mononuclear iron enzyme]]
[[Category: Substrate-enzyme complex]]
[[Category: Substrate-enzyme complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:15:54 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:03:27 2008''

Revision as of 11:03, 27 July 2008

File:1zz8.png


Drag the structure with the mouse to rotate
1zz8, resolution 2.30Å (default scene)
Ligands: FE2, S0H
Gene: fom4 (Streptomyces wedmorensis)
Related: 1zz6, 1zz7, 1zz9, 1zzb, 1zzc
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of FeII HppE in Complex with Substrate Form 2

Template:ABSTRACT PUBMED 16015285

About this Structure

1ZZ8 is a Single protein structure of sequence from Streptomyces wedmorensis. Full crystallographic information is available from OCA.

Reference

Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme., Higgins LJ, Yan F, Liu P, Liu HW, Drennan CL, Nature. 2005 Oct 6;437(7060):838-44. Epub 2005 Jul 13. PMID:16015285

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