1y6e: Difference between revisions

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[[Image:1y6e.gif|left|200px]]
{{Seed}}
[[Image:1y6e.png|left|200px]]


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{{STRUCTURE_1y6e|  PDB=1y6e  |  SCENE=  }}  
{{STRUCTURE_1y6e|  PDB=1y6e  |  SCENE=  }}  


'''Orthorhombic glutathione S-transferase of Schistosoma japonicum'''
===Orthorhombic glutathione S-transferase of Schistosoma japonicum===




==Overview==
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The crystal structure of the 26 kDa glutathione S-transferase from Schistosoma japonicum (SjGST) was determined at 3 A resolution in the new space group P2(1)2(1)2(1). The structure of orthorhombic SjGST reveals unique features of the ligand-binding site and dimer interface when compared with previously reported structures. SjGST is recognized as the major detoxification enzyme of S. japonicum, a pathogenic helminth causing schistosomiasis. As resistance against the established inhibitor of SjGST, praziquantel, has been reported these results might prove to be valuable for the development of novel drugs.
The line below this paragraph, {{ABSTRACT_PUBMED_16511012}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16511012}}


==About this Structure==
==About this Structure==
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[[Category: Thiebach, L.]]
[[Category: Thiebach, L.]]
[[Category: Dimer]]
[[Category: Dimer]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:55:29 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:16:03 2008''

Revision as of 11:16, 27 July 2008

File:1y6e.png

Template:STRUCTURE 1y6e

Orthorhombic glutathione S-transferase of Schistosoma japonicum

Template:ABSTRACT PUBMED 16511012

About this Structure

1Y6E is a Single protein structure of sequence from Schistosoma japonicum. Full crystallographic information is available from OCA.

Reference

X-ray structure of glutathione S-transferase from Schistosoma japonicum in a new crystal form reveals flexibility of the substrate-binding site., Rufer AC, Thiebach L, Baer K, Klein HW, Hennig M, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Mar 1;61(Pt, 3):263-5. Epub 2005 Feb 24. PMID:16511012

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