2veq: Difference between revisions

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[[Image:2veq.jpg|left|200px]]
{{Seed}}
[[Image:2veq.png|left|200px]]


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{{STRUCTURE_2veq|  PDB=2veq  |  SCENE=  }}  
{{STRUCTURE_2veq|  PDB=2veq  |  SCENE=  }}  


'''INSIGHTS INTO KINETOCHORE-DNA INTERACTIONS FROM THE STRUCTURE OF CEP3P'''
===INSIGHTS INTO KINETOCHORE-DNA INTERACTIONS FROM THE STRUCTURE OF CEP3P===




==Overview==
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The CBF3 complex is an essential core component of the budding yeast kinetochore and is required for the centromeric localization of all other kinetochore proteins. We determined the crystal structure of a large section of the protein Cep3 from CBF3, which is the only component with obvious DNA-binding motifs. The protein adopts a roughly bilobal shape, with an extended dimerization interface. The dimer has a large central channel that is sufficient to accommodate duplex B-form DNA. The zinc-finger domains emerge at the edges of the channel, and could bind to the DNA in a pseudo-symmetrical manner at degenerate half-sites in the centromeric sequence. We propose a mechanism for the modulation of DNA affinity by an acidic activator domain, which could be applicable to a wider family of transcription factors.
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{{ABSTRACT_PUBMED_18064045}}


==About this Structure==
==About this Structure==
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[[Category: Transcription factor]]
[[Category: Transcription factor]]
[[Category: Zinc]]
[[Category: Zinc]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 18:40:53 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:17:09 2008''

Revision as of 11:17, 27 July 2008

File:2veq.png

Template:STRUCTURE 2veq

INSIGHTS INTO KINETOCHORE-DNA INTERACTIONS FROM THE STRUCTURE OF CEP3P

Template:ABSTRACT PUBMED 18064045

About this Structure

2VEQ is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Insights into kinetochore-DNA interactions from the structure of Cep3Delta., Purvis A, Singleton MR, EMBO Rep. 2008 Jan;9(1):56-62. Epub 2007 Dec 7. PMID:18064045

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