2nna: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:2nna.jpg|left|200px]]
{{Seed}}
[[Image:2nna.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2nna|  PDB=2nna  |  SCENE=  }}  
{{STRUCTURE_2nna|  PDB=2nna  |  SCENE=  }}  


'''Structure of the MHC class II molecule HLA-DQ8 bound with a deamidated gluten peptide'''
===Structure of the MHC class II molecule HLA-DQ8 bound with a deamidated gluten peptide===




==Overview==
<!--
The risk of celiac disease is strongly associated with human leukocyte antigen (HLA) DQ2 and to a lesser extent with HLA DQ8. Although the pathogenesis of HLA-DQ2-mediated celiac disease is established, the underlying basis for HLA-DQ8-mediated celiac disease remains unclear. We showed that T helper 1 (Th1) responses in HLA-DQ8-associated celiac pathology were indeed HLA DQ8 restricted and that multiple, mostly deamidated peptides derived from protease-sensitive sites of gliadin were recognized. This pattern of reactivity contrasted with the more absolute deamidation dependence and relative protease resistance of the dominant gliadin peptide in DQ2-mediated disease. We provided a structural basis for the selection of HLA-DQ8-restricted, deamidated gliadin peptides. The data established that the molecular mechanisms underlying HLA-DQ8-mediated celiac disease differed markedly from the HLA-DQ2-mediated form of the disease. Accordingly, nondietary therapeutic interventions in celiac disease might need to be tailored to the genotype of the individual.
The line below this paragraph, {{ABSTRACT_PUBMED_17629515}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17629515 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_17629515}}


==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Major histocompatibility complex hla-dq8]]
[[Category: Major histocompatibility complex hla-dq8]]
[[Category: Post translational modification]]
[[Category: Post translational modification]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:39:48 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:30:15 2008''
Retrieved from "https://proteopedia.org/2nna"