2nw0: Difference between revisions

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[[Image:2nw0.gif|left|200px]]
{{Seed}}
[[Image:2nw0.png|left|200px]]


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{{STRUCTURE_2nw0|  PDB=2nw0  |  SCENE=  }}  
{{STRUCTURE_2nw0|  PDB=2nw0  |  SCENE=  }}  


'''Crystal structure of a lysin'''
===Crystal structure of a lysin===




==Overview==
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Lysins are peptidoglycan hydrolases that are produced by bacteriophage and act to lyse the bacterial host cell wall during progeny phage release. Here, we describe the structure and function of a novel bacteriophage-derived lysin, PlyB, which displays potent lytic activity against the Bacillus anthracis-like strain ATCC 4342. This molecule comprises an N-terminal catalytic domain (PlyB(cat)) and a C-terminal bacterial SH3-like domain, SH3b. It is shown that both domains are required for effective catalytic activity against ATCC 4342. Further, PlyB has specific activity comparable to the phage lysin PlyG, an amidase being developed as a therapeutic against anthrax. In contrast to PlyG, however, the 1.6 A X-ray crystal structure of PlyB(cat) reveals that the catalytic domain adopts the glycosyl hydrolase (GH)-25, rather than phage T7 lysozyme-like fold. PlyB therefore represents a new class of anthrax lysin and a new defensive tool in the armament against anthrax-mediated bioterrorism.
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{{ABSTRACT_PUBMED_17182056}}


==About this Structure==
==About this Structure==
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[[Category: Whisstock, J C.]]
[[Category: Whisstock, J C.]]
[[Category: Beta barrel]]
[[Category: Beta barrel]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:58:36 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:32:22 2008''

Revision as of 11:32, 27 July 2008

File:2nw0.png

Template:STRUCTURE 2nw0

Crystal structure of a lysin

Template:ABSTRACT PUBMED 17182056

About this Structure

Full crystallographic information is available from OCA.

Reference

The 1.6 A crystal structure of the catalytic domain of PlyB, a bacteriophage lysin active against Bacillus anthracis., Porter CJ, Schuch R, Pelzek AJ, Buckle AM, McGowan S, Wilce MC, Rossjohn J, Russell R, Nelson D, Fischetti VA, Whisstock JC, J Mol Biol. 2007 Feb 16;366(2):540-50. Epub 2006 Nov 18. PMID:17182056

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