2au1: Difference between revisions

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[[Image:2au1.gif|left|200px]]
{{Seed}}
[[Image:2au1.png|left|200px]]


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{{STRUCTURE_2au1|  PDB=2au1  |  SCENE=  }}  
{{STRUCTURE_2au1|  PDB=2au1  |  SCENE=  }}  


'''Crystal Structure of group A Streptococcus MAC-1 orthorhombic form'''
===Crystal Structure of group A Streptococcus MAC-1 orthorhombic form===




==Overview==
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Group A Streptococcus secretes cysteine proteases named Mac-1 and Mac-2 that mediate host immune evasion by targeting both IgG and Fc receptors. Here, we report the crystal structures of Mac-1 and its catalytically inactive C94A mutant in two different crystal forms. Despite the lack of sequence homology, Mac-1 adopts the canonical papain fold. Alanine mutations at the active site confirmed the critical residues involved in a papain-like catalytic mechanism. Mac-1 forms a symmetric dimer in both crystal forms and displays the unique dimer interface among papain superfamily members. Mutations at the dimer interface resulted in a significant reduction in IgG binding and catalysis, suggesting that the dimer contributes to both IgG specificity and enzyme cooperativity. A tunnel observed at the dimer interface constitutes a target for designing potential Mac-1-specific antimicrobial agents. The structures also offer insight into the functional difference between Mac-1 and Mac-2.
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{{ABSTRACT_PUBMED_16472742}}


==About this Structure==
==About this Structure==
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[[Category: Sun, P D.]]
[[Category: Sun, P D.]]
[[Category: Mac-1]]
[[Category: Mac-1]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:28:44 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:36:51 2008''

Revision as of 11:36, 27 July 2008

File:2au1.png

Template:STRUCTURE 2au1

Crystal Structure of group A Streptococcus MAC-1 orthorhombic form

Template:ABSTRACT PUBMED 16472742

About this Structure

2AU1 is a Single protein structure of sequence from Streptococcus pyogenes mgas5005. Full crystallographic information is available from OCA.

Reference

Crystal structure of group A streptococcus Mac-1: insight into dimer-mediated specificity for recognition of human IgG., Agniswamy J, Nagiec MJ, Liu M, Schuck P, Musser JM, Sun PD, Structure. 2006 Feb;14(2):225-35. PMID:16472742

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