2fie: Difference between revisions

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[[Image:2fie.~~gif~~|left|200px]]

[[Image:2fie.png|left|200px]]

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~~'''~~Structure of human liver FBPase complexed with potent benzoxazole allosteric inhibitors~~'''~~

===Structure of human liver FBPase complexed with potent benzoxazole allosteric inhibitors===

~~==Overview==~~

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~~A series of novel benzoxazole benzenesulfonamides was synthesized as inhibitors of fructose~~-~~1,6~~-~~bisphosphatase (FBPase-1). Extensive SAR studies led to a potent inhibitor~~, 53, ~~with an IC~~(~~50) of 0~~.~~57microM~~. ~~Compound 17 exhibited excellent bioavailability and a good pharmacokinetic profile in rats~~.

The line below this paragraph, {{ABSTRACT_PUBMED_16446092}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16446092 is the PubMed ID number.

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==About this Structure==

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==Reference==

Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase., Lai C, Gum RJ, Daly M, Fry EH, Hutchins C, Abad-Zapatero C, von Geldern TW, Bioorg Med Chem Lett. 2006 Apr 1;16(7):1807-10. Epub 2006 Jan 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16446092 16446092]

Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode., von Geldern TW, Lai C, Gum RJ, Daly M, Sun C, Fry EH, Abad-Zapatero C, Bioorg Med Chem Lett. 2006 Apr 1;16(7):1811-5. Epub 2006 Jan 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16442285 16442285]

[[Category: Fructose-bisphosphatase]]

[[Category: Homo sapiens]]

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[[Category: Benzoxazole]]

[[Category: Intersubunit allosteric inhibitors of human liver fbpase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~May 4 03~~:56:07 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:54:52 2008''

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-[[Image:2fie.gif|left|200px]]
+{{Seed}}
+[[Image:2fie.png|left|200px]]
 <!--
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 {{STRUCTURE_2fie|  PDB=2fie  |  SCENE=  }}
-'''Structure of human liver FBPase complexed with potent benzoxazole allosteric inhibitors'''
+===Structure of human liver FBPase complexed with potent benzoxazole allosteric inhibitors===
-==Overview==
+<!--
-A series of novel benzoxazole benzenesulfonamides was synthesized as inhibitors of fructose-1,6-bisphosphatase (FBPase-1). Extensive SAR studies led to a potent inhibitor, 53, with an IC(50) of 0.57microM. Compound 17 exhibited excellent bioavailability and a good pharmacokinetic profile in rats.
+The line below this paragraph, {{ABSTRACT_PUBMED_16446092}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16446092 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16446092}}
 ==About this Structure==
@@ Line 20: / Line 24: @@
 ==Reference==
 Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase., Lai C, Gum RJ, Daly M, Fry EH, Hutchins C, Abad-Zapatero C, von Geldern TW, Bioorg Med Chem Lett. 2006 Apr 1;16(7):1807-10. Epub 2006 Jan 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16446092 16446092]
+Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode., von Geldern TW, Lai C, Gum RJ, Daly M, Sun C, Fry EH, Abad-Zapatero C, Bioorg Med Chem Lett. 2006 Apr 1;16(7):1811-5. Epub 2006 Jan 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16442285 16442285]
 [[Category: Fructose-bisphosphatase]]
 [[Category: Homo sapiens]]
@@ Line 27: / Line 33: @@
 [[Category: Benzoxazole]]
 [[Category: Intersubunit allosteric inhibitors of human liver fbpase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:56:07 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:54:52 2008''