1shc: Difference between revisions

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[[Image:1shc.~~jpg~~|left|200px]]

[[Image:1shc.png|left|200px]]

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~~'''~~SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE~~'''~~

===SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE===

~~==Overview==~~

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The ~~nuclear magnetic resonance structure of~~ the ~~phosphotyrosine binding (PTB) domain of Shc complexed~~ to a phosphopeptide reveals an alternative means of recognizing tyrosine-phosphorylated proteins. Unlike in SH2 domains, the phosphopeptide forms an antiparallel beta-strand with a beta-sheet of the protein, interacts with a hydrophobic pocket through the (~~pY-5~~) ~~residue~~, ~~and adopts a beta-turn~~. ~~The PTB domain is structurally similar to pleckstrin homology domains (a beta~~-~~sandwich capped by an alpha~~-~~helix) and binds to acidic phospholipids, suggesting a possible role in membrane localization.~~

The line below this paragraph, {{ABSTRACT_PUBMED_8524391}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 8524391 is the PubMed ID number.

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==About this Structure==

1SHC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHC OCA].

1SHC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHC OCA].

==Reference==

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[[Category: Wade, W S.]]

[[Category: Zhou, M M.]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 08~~:42~~:26~~ 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:06:42 2008''

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-[[Image:1shc.jpg|left|200px]]
+{{Seed}}
+[[Image:1shc.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1shc|  PDB=1shc  |  SCENE=  }}
-'''SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE'''
+===SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE===
-==Overview==
+<!--
-The nuclear magnetic resonance structure of the phosphotyrosine binding (PTB) domain of Shc complexed to a phosphopeptide reveals an alternative means of recognizing tyrosine-phosphorylated proteins. Unlike in SH2 domains, the phosphopeptide forms an antiparallel beta-strand with a beta-sheet of the protein, interacts with a hydrophobic pocket through the (pY-5) residue, and adopts a beta-turn. The PTB domain is structurally similar to pleckstrin homology domains (a beta-sandwich capped by an alpha-helix) and binds to acidic phospholipids, suggesting a possible role in membrane localization.
+The line below this paragraph, {{ABSTRACT_PUBMED_8524391}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8524391 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8524391}}
 ==About this Structure==
-SHC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHC OCA].
+SHC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHC OCA].
 ==Reference==
@@ Line 32: / Line 36: @@
 [[Category: Wade, W S.]]
 [[Category: Zhou, M M.]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:42:26 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:06:42 2008''