2b8v: Difference between revisions

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[[Image:2b8v.gif|left|200px]]
{{Seed}}
[[Image:2b8v.png|left|200px]]


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{{STRUCTURE_2b8v|  PDB=2b8v  |  SCENE=  }}  
{{STRUCTURE_2b8v|  PDB=2b8v  |  SCENE=  }}  


'''Crystal structure of human Beta-secretase complexed with L-L000430,469'''
===Crystal structure of human Beta-secretase complexed with L-L000430,469===




==Overview==
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We have synthesized and evaluated a series of conformationally biased P3 amide replacements based on an isophthalamide lead structure. The studies resulted in the identification of the beta-secretase inhibitor 7m which has an in vitro IC(50)=35 nM. The synthesis and biological activities of these compounds are described.
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{{ABSTRACT_PUBMED_16263281}}


==About this Structure==
==About this Structure==
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[[Category: Aspartyl protease]]
[[Category: Aspartyl protease]]
[[Category: Bace]]
[[Category: Bace]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:59:42 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:28:28 2008''