2adu: Difference between revisions

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[[Image:2adu.gif|left|200px]]
{{Seed}}
[[Image:2adu.png|left|200px]]


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{{STRUCTURE_2adu|  PDB=2adu  |  SCENE=  }}  
{{STRUCTURE_2adu|  PDB=2adu  |  SCENE=  }}  


'''Human Methionine Aminopeptidase Complex with 4-Aryl-1,2,3-triazole Inhibitor'''
===Human Methionine Aminopeptidase Complex with 4-Aryl-1,2,3-triazole Inhibitor===




==Overview==
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Inhibitors of human methionine aminopeptidase type 2 (hMetAP2) are of interest as potential treatments for cancer. A new class of small molecule reversible inhibitors of hMetAP2 was discovered and optimized, the 4-aryl-1,2,3-triazoles. Compound 24, a potent inhibitor of cobalt-activated hMetAP2, also inhibits human and mouse endothelial cell growth. Using a mouse matrigel model, this reversible hMetAP2 inhibitor was also shown to inhibit angiogenesis in vivo.
The line below this paragraph, {{ABSTRACT_PUBMED_16134930}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16134930 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16134930}}


==About this Structure==
==About this Structure==
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[[Category: Metal binding]]
[[Category: Metal binding]]
[[Category: Protease]]
[[Category: Protease]]
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