2nxp: Difference between revisions

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[[Image:2nxp.gif|left|200px]]
{{Seed}}
[[Image:2nxp.png|left|200px]]


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{{STRUCTURE_2nxp|  PDB=2nxp  |  SCENE=  }}  
{{STRUCTURE_2nxp|  PDB=2nxp  |  SCENE=  }}  


'''Structure of NTD2 domain of the human TAF5 subunit of TFIID'''
===Structure of NTD2 domain of the human TAF5 subunit of TFIID===




==Overview==
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TFIID is an essential factor required for RNA polymerase II transcription but remains poorly understood because of its intrinsic complexity. Human TAF5, a 100-kDa subunit of general transcription factor TFIID, is an essential gene and plays a critical role in assembling the 1.2 MDa TFIID complex. We report here a structural analysis of the TAF5 protein. Our structure at 2.2-A resolution of the TAF5-NTD2 domain reveals an alpha-helical domain with distant structural similarity to RNA polymerase II CTD interacting factors. The TAF5-NTD2 domain contains several conserved clefts likely to be critical for TFIID complex assembly. Our biochemical analysis of the human TAF5 protein demonstrates the ability of the N-terminal half of the TAF5 gene to form a flexible, extended dimer, a key property required for the assembly of the TFIID complex.
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{{ABSTRACT_PUBMED_17227857}}


==About this Structure==
==About this Structure==
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[[Category: Tfiid subunit]]
[[Category: Tfiid subunit]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
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